Raimon Puig De La Bellacasa Cazorla

2025

Rational Method for Structural Simplification as Key Step in Hit Discovery: The Case of FGFR2 and IGF1R Dual Inhibitors

Torres-Urtizberea, E., Borrell, J. I., Puig de la Bellacasa, R. & Estrada-Tejedor, R., May 2025, In: International Journal of Molecular Sciences. 26, 9, 16 p., 4457.

Research output: Indexed journal article › Article › peer-review

Open Access

2024

Applying Molecular Modeling to the Design of Innovative, Non-Symmetrical CXCR4 Inhibitors with Potent Anticancer Activity

Martínez-Asensio, M., Sàrrias, L., Gorjón-de-Pablo, G., Fernández-Serrano, M., Camaló-Vila, J., Gibert, A., Puig de la Bellacasa, R., Teixidó, J., Roué, G., Borrell, J. I. & Estrada-Tejedor, R., Sept 2024, In: International Journal of Molecular Sciences. 25, 17, 14 p., 9446.

Research output: Indexed journal article › Article › peer-review

Open Access

Autocatalytic photoinduced oxidative dehydrogenation of pyrido[2,3-d]pyrimidin-7(8H)-ones: synthesis of C5-C6 unsaturated systems with concomitant formation of a long-lived radical

de Rocafiguera, C., Lloveras, V., Vidal-Gancedo, J., Teixidó, J., Estrada-Tejedor, R., Borrell, J. I. & Puig de la Bellacasa, R., 7 Jan 2024, In: Organic Chemistry Frontiers. 11, 1, p. 27-36 11 p.

Research output: Indexed journal article › Article › peer-review

Open Access

1 Citation (Scopus)

From propenolysis to enyne metathesis: tools for expedited assembly of 4a,8a-azaboranaphthalene and extended polycycles with embedded BN

Rulli, F., Sanz-Liarte, G., Roca, P., Martínez, N., Medina, V., Puig de la Bellacasa, R., Shafir, A. & Cuenca, A. B., Apr 2024, In: Chemical Science. 15, 15, p. 5674-5680 7 p.

Research output: Indexed journal article › Article › peer-review

Open Access

2 Citations (Scopus)

The Use of a Penta-Deuterophenyl Substituent to Improve the Metabolic Stability of a Tyrosine Kinase Inhibitor

Dulsat, J., Puig de la Bellacasa, R. & Borrell, J. I., Dec 2024, In: Molecules. 29, 24, 13 p., 6042.

Research output: Indexed journal article › Article › peer-review

Open Access

When Unsuspected Crystallinity Ruins Biological Testing in Early Discovery: A Case Study

de Rocafiguera, C., Belsa, B., Font-Bardia, M., Puigjaner, C., Serra, E., Cuartero-Albesa, A. M., Puig de la Bellacasa, R. & Borrell, J. I., Mar 2024, In: Pharmaceuticals. 17, 3, 13 p., 284.

Research output: Indexed journal article › Article › peer-review

Open Access

2022

1H-Pyrazolo[3,4-b]pyridines: synthesis and biomedical applications

Donaire-Arias, A., Montagut, A. M., Puig de la Bellacasa, R., Estrada-Tejedor, R., Teixidó, J. & Borrell, J. I., 30 May 2022, In: Molecules. 27, 7, 2237.

Research output: Indexed journal article › Review › peer-review

Open Access

46 Citations (Scopus)

Optimitzar l'obtenció d'hupertacrina-tacrina per tractar la malaltia d'Alzheimer

Comallonga Albareda, C., Borrell Bilbao, J. I. & Puig De La Bellacasa Cazorla, R., 1 Jan 2022, In: Circular farmacèutica. 80, Especial Beques i Premis, p. 27-29 3 p.

Research output: Indexed journal article › Article

2021

1,6-naphthyridin-2(1h)-ones: synthesis and biomedical applications

Oliveras, J. M., de la Bellacasa, R. P., Estrada-Tejedor, R., Teixidó, J. & Borrell, J. I., Oct 2021, In: Pharmaceuticals. 14, 10, 15 p., 1029.

Research output: Indexed journal article › Review › peer-review

Open Access

3 Citations (Scopus)

Expanding the diversity at the C-4 position of pyrido[2,3-d]pyrimidin-7(8H)-ones to achieve biological activity against ZAP-70

Masip, V., Lirio, Á., Sánchez-López, A., Cuenca, A. B., Puig de la Bellacasa, R., Abrisqueta, P., Teixidó, J., Borrell, J. I., Gibert, A. & Estrada-Tejedor, R., 15 Dec 2021, In: Pharmaceuticals. 14, 12, 1311.

Research output: Indexed journal article › Article › peer-review

Open Access

2 Citations (Scopus)

The Versatile Reaction Chemistry of an Alpha-Boryl Diazo Compound

Liu, Y., Puig De La Bellacasa, R., Li, B., Cuenca, A. B. & Liu, S. Y., 8 Sept 2021, In: Journal of the American Chemical Society. 143, 35, p. 14059-14064 6 p.

Research output: Indexed journal article › Article › peer-review

14 Citations (Scopus)

2020

A captured room temperature stable Wheland intermediate as a key structure for the orthogonal decoration of 4-amino-pyrido[2,3-d]pyrimidin-7(8H)-ones

Galve, I., Ondoño, R., de Rocafiguera, C., Puig de la Bellacasa, R., Batllori, X., Puigjaner, C., Font-Bardia, M., Vallcorba, O., Teixidó, J. & Borrell, J. I., 28 Dec 2020, In: Organic and Biomolecular Chemistry. 18, 48, p. 9810-9815 6 p.

Research output: Indexed journal article › Article › peer-review

5 Citations (Scopus)

2019

Pyrido[2,3-d]pyrimidin-7(8H)-ones: synthesis and biomedical applications

Jubete, G., Puig de la Bellacasa, R., Estrada-Tejedor, R., Teixidó, J. & Borrell, J. I., 16 Nov 2019, In: Molecules. 24, 22, 4161.

Research output: Indexed journal article › Review › peer-review

Open Access

30 Citations (Scopus)

2017

5-Amino-6,7,8,9-Tetrahydrobenzo[b][1,8]Naphthyridin-2(1H)-One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy

Balmori, A., Chioua, M., de la Bellacasa, R. P., Estrada-Tejedor, R., Ismaili, L., Marco-Contelles, J. & Borrell, J. I., 13 Mar 2017, In: ChemistrySelect. 2, 8, p. 2605-2610 6 p.

Research output: Indexed journal article › Article › peer-review

3 Citations (Scopus)

Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma

Balsas, P., Esteve-Arenys, A., Roldán, J., Jiménez, L., Rodríguez, V., Valero, J. G., Chamorro-Jorganes, A., De La Bellacasa, R. P., Teixidó, J., Matas-Céspedes, A., Moros, A., Martínez, A., Campo, E., Sáez-Borderías, A., Borrell, J. I., Pérez-Galán, P., Colomer, D. & Roué, G., 31 Mar 2017, In: Journal of Hematology and Oncology. 10, 1, 14 p., 80.

Research output: Indexed journal article › Article › peer-review

Open Access

10 Citations (Scopus)

An unequivocal synthesis of 2-aryl substituted 3-amino-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-ones

Bou-Petit, E., Picas, E., Puigjaner, C., Font-Bardia, M., Ferrer, N., Sempere, J., Puig de la Bellacasa, R., Batllori, X., Teixidó, J., Estrada-Tejedor, R., Ramon y Cajal, S. & Borrell, J. I., 2 May 2017, In: ChemistrySelect. 2, 13, p. 3668-3672 5 p.

Research output: Indexed journal article › Article › peer-review

5 Citations (Scopus)

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC

Chaib, I., Karachaliou, N., Pilotto, S., Codony Servat, J., Cai, X., Li, X., Drozdowskyj, A., Servat, C. C., Yang, J., Hu, C., Cardona, A. F., Vivanco, G. L., Vergnenegre, A., Sanchez, J. M., Provencio, M., de Marinis, F., Passaro, A., Cao, P., Reguart, N. & Campelo, C. G. & 21 others, Teixido, C., Sperduti, I., Rodriguez, S., Lazzari, C., Verlicchi, A., de Aguirre, I., Queralt, C., Wei, J., Estrada, R., de la Bellacasa, R. P., Ramirez, J. L., Jacobsen, K., Ditzel, H. J., Santarpia, M., Viteri, S., Molina, M. A., Zhou, C., Cao, P., Ma, P. C., Bivona, T. G. & Rosell, R., 1 Sept 2017, In: Journal of the National Cancer Institute. 109, 9

Research output: Indexed journal article › Article › peer-review

Open Access

136 Citations (Scopus)

2016

Cotargeting EGFR, STAT3 and Src-Notch pathways: a promising approach to improve the efficacy of EGFR-TKIs in the treatment of NSCLC patients

Karachaliou, N., Chaib, L., Pilotto, S., Codony, J., Cai, X., Li, X., Drozdowskyj, A., Codony, C., Cardona, A. F., Lopez-Vivanco, G., Vergnenegre, A., Sanchez, J. M., Provencio, M., de Marinis, F., Carcereny, E., Reguart, N., Garcia-Campelo, R., Marin, S., Teixido, C. & Sperduti, I. & 10 others, Rodriguez, S., Estrada, R., de la Bellacasa, R. P., Ramirez, J. L., Molina-Vila, M. A., Zhou, C., Cao, P., Ma, P., Bivona, T. & Rosell, R., Jul 2016, In: Cancer Research. 76, 14 Supplement, 4 p., 265.

Research output: Indexed journal article › Meeting Abstract › peer-review

Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors

Camarasa, M., De La Bellacasa, R. P., González, À. L., Ondoño, R., Estrada, R., Franco, S., Badia, R., Esté, J., Martínez, M. Á., Teixidó, J., Clotet, B. & Borrell, J. I., 10 Jun 2016, In: European Journal of Medicinal Chemistry. 115, p. 463-483 21 p.

Research output: Indexed journal article › Article › peer-review

15 Citations (Scopus)

Investigating molecular dynamics-guided lead optimization of EGFR inhibitors

Lavecchia, M. J., Puig De La Bellacasa, R., Borrell, J. I. & Cavasotto, C. N., 15 Feb 2016, In: Bioorganic and Medicinal Chemistry. 24, 4, p. 768-778 11 p.

Research output: Indexed journal article › Article › peer-review

11 Citations (Scopus)

Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors

Puig De La Bellacasa, R., Gibert, A., Planesas, J. M., Ros-Blanco, L., Batllori, X., Badía, R., Clotet, B., Esté, J., Teixidó, J. & Borrell, J. I., 2016, In: Organic and Biomolecular Chemistry. 14, 4, p. 1455-1472 18 p.

Research output: Indexed journal article › Article › peer-review

Open Access

3 Citations (Scopus)

PB1, a DDR2 inhibitor with antitumor activity in preclinical models of squamous cell carcinoma and KRAS-mutated adenocarcinoma of the lung

Garcia-Roman, S., Molina, M. A., Borrell, J. I., de la Bellacasa, R. P., Morales, D., Bertran, J., Gimenez, A., Karachaliou, N. & Rosell, R., 15 Jul 2016, In: Cancer Research. 76, 4 p.

Research output: Indexed journal article › Meeting Abstract › peer-review

3 Citations (Web of Science)

2015

Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer’s disease

Chioua, M., Pérez, M., Bautista-Aguilera, O. M., Yañez, M., López, M. G., Romero, A., Cacabelos, R., de la Bellacasa, R. P., Brogi, S., Butini, S., Borrell, J. I. & Marco-Contelles, J., 1 May 2015, In: Mini-Reviews in Medicinal Chemistry. 15, 8, p. 648-658 11 p.

Research output: Indexed journal article › Review › peer-review

13 Citations (Scopus)

PB1 a new DDR2 inhibitor: Potential treatment to SCC patients

Silvia, G., Molina-Vila, M. A., Borrell, J. I., Puig de la Bellacasa, R., Morales, D., Bertran-Alamillo, J., Gimenez-Capitan, A., Karachaliou, N. & Rosell, R., Sept 2015, In: European Journal of Cancer. 51, p. S642-S642 1 p.

Research output: Indexed journal article › Meeting Abstract › peer-review

Preclinical evaluation of IQS019, a novel BCR kinase inhibitor, in in vitro and in vivo models of non-Hodgkin lymphoma

Balsas, P., Roldan, J., Jimenez, L., Rodriguez, V., Puig de la Bellacasa, R., Teixido, J., Matas-Cespedes, A., Moros, A., Martinez, A., Campo, E., Borrell, J. I., Perez-Galan, P., Colomer, D. & Roue, G., 1 Aug 2015, In: Cancer Research. 75, 15 Supplement, 3 p.

Research output: Indexed journal article › Meeting Abstract › peer-review

2014

4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3- d ]pyrimidin-7-(8 H)-ones as BCR kinase inhibitors for B lymphoid malignancies

Puig De La Bellacasa, R., Roué, G., Balsas, P., Pérez-Galán, P., Teixidó, J., Colomer, D. & Borrell, J. I., 30 Oct 2014, In: European Journal of Medicinal Chemistry. 86, p. 664-675 12 p.

Research output: Indexed journal article › Article › peer-review

23 Citations (Scopus)

Synthetic lethal combinations in KRAS NSCLC cell lines combining gefitinib/erlotinib with an AXL inhibitor: Compound 16

García Román, S., Puig De La Bellacasa Cazorla, R., Molina, M. A., Bertran, J., Codony Servat, J., Borrell Bilbao, J. I. & Rosell, R., 20 Nov 2014.

Research output: Conference paper › Contribution

2013

ALK and ROS1 as a joint target for the treatment of lung cancer: A review

de la Bellacasa, R. P., Karachaliou, N., Estrada-Tejedor, R., Teixidó, J., Costa, C. & Borrell, J. I., 2013, In: Translational Lung Cancer Research. 2, 2, p. 72-86 15 p.

Research output: Indexed journal article › Review › peer-review

45 Citations (Scopus)

A new and practical method for the synthesis of 6-aryl-5,6-dihydropyrido[2, 3-d]pyrimidine-4,7(3H,8H)-diones

Camarasa, M., Barnils, C., Puig De La Bellacasa, R., Teixidó, J. & Borrell, J. I., Aug 2013, In: Molecular Diversity. 17, 3, p. 525-536 12 p.

Research output: Indexed journal article › Article › peer-review

11 Citations (Scopus)

2012

Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors

Puig-De-La-Bellacasa, R., Giménez, L., Pettersson, S., Pascual, R., Gonzalo, E., Esté, J. A., Clotet, B., Borrell, J. I. & Teixidó, J., Aug 2012, In: European Journal of Medicinal Chemistry. 54, p. 159-174 16 p.

Research output: Indexed journal article › Article › peer-review

18 Citations (Scopus)

Synthesis of 2-Arylamino substituted 5,6-dihydropyrido[2,3-d]pyrimidine- 7(8H)-ones from arylguanidines

Galve, I., Puig De La Bellacasa, R., Sánchez-García, D., Batllori, X., Teixidó, J. & Borrell, J. I., Nov 2012, In: Molecular Diversity. 16, 4, p. 639-649 11 p.

Research output: Indexed journal article › Article › peer-review

17 Citations (Scopus)

2008

Discovery of novel non-cyclam polynitrogenated CXCR4 coreceptor inhibitors

Pettersson, S., Pérez-Nueno, V. I., Ros-Blanco, L., De La Bellacasa, R. P., Rabal, M. O., Batllori, X., Clotet, B., Clotet-Codina, I., Armand-Ugón, M., Esté, J., Borrell, J. I. & Teixidó, J., 20 Oct 2008, In: ChemMedChem. 3, 10, p. 1549-1557 9 p.

Research output: Indexed journal article › Article › peer-review

19 Citations (Scopus)

2007

Molècules Contra la Sida: Consciència URL

Pettersson, S., Perez Nueno, V. I., Ros Blanco, L., Puig De La Bellacasa Cazorla, R., Estrada Tejedor, R., Alavedra, R., Borrell Bilbao, J. I. & Teixidó Closa, J., 2007, Barcelona, ES.

Research output: Working paper

Nous fàrmacs per bloquejar l'entrada del VIH a les cèl·lules

Pettersson, S., Perez Nueno, V. I., Ros Blanco, L., Puig De La Bellacasa Cazorla, R., Estrada Tejedor, R., Borrell, J. I., Alavedra, R. & Teixidó Closa, J., Oct 2007, Teraflop, Revista del Centre de Supercomputació de Catalunya., 94, p. 14-15 2 p.

Research output: Not indexed journal article › Article

Open Access

Raimon Puig De La Bellacasa Cazorla

Research output

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