TY - JOUR
T1 - 1H-Pyrazolo[3,4-b]pyridines
T2 - synthesis and biomedical applications
AU - Donaire-Arias, Ana
AU - Montagut, Ana Maria
AU - Puig de la Bellacasa, Raimon
AU - Estrada-Tejedor, Roger
AU - Teixidó, Jordi
AU - Borrell, José I.
N1 - Funding Information:
This research was funded by Ministerio de Ciencia, Innovación y Universidades, Proyectos de I + D + I “Retos Investigación” del Programa Estatal de I+D+I orientada a los Retos de la Sociedad, grant number RTI2018-096455-B-I00.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5/30
Y1 - 2022/5/30
N2 - Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 patents) up to date. This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, and C6, the synthetic methods used for their synthesis, starting from both a preformed pyrazole or pyridine, and the biomedical applications of such compounds.
AB - Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 patents) up to date. This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, and C6, the synthetic methods used for their synthesis, starting from both a preformed pyrazole or pyridine, and the biomedical applications of such compounds.
KW - 1H-pyrazolo[3,4-b]pyridines
KW - biological activity
KW - substitution pattern
KW - synthesis
UR - http://www.scopus.com/inward/record.url?scp=85128078922&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000781989300001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.3390/molecules27072237
DO - 10.3390/molecules27072237
M3 - Review
C2 - 35408636
AN - SCOPUS:85128078922
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 7
M1 - 2237
ER -