1H-Pyrazolo[3,4-b]pyridines: synthesis and biomedical applications

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Abstract

Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 patents) up to date. This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, and C6, the synthetic methods used for their synthesis, starting from both a preformed pyrazole or pyridine, and the biomedical applications of such compounds.

Original languageEnglish
Article number2237
JournalMolecules
Volume27
Issue number7
DOIs
Publication statusPublished - 30 May 2022

Keywords

  • 1H-pyrazolo[3,4-b]pyridines
  • biological activity
  • substitution pattern
  • synthesis

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