5-Amino-6,7,8,9-Tetrahydrobenzo[b][1,8]Naphthyridin-2(1H)-One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy

Alba Balmori, Mourad Chioua, Raimon Puig de la Bellacasa, Roger Estrada-Tejedor, Lhassane Ismaili, José Marco-Contelles, José I. Borrell

Research output: Indexed journal article Articlepeer-review

3 Citations (Scopus)

Abstract

In this communication we have described the synthesis of 2-amino-6-oxo-1,6-dihydropyridine-3-carbonitrile (4), and the preparation of 5-amino-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridin-2(1H)-one (3 a), a non-hepatotoxic, antioxidant agent, showing moderate, but selective human acetylcholinesterase inhibition.

Original languageEnglish
Pages (from-to)2605-2610
Number of pages6
JournalChemistrySelect
Volume2
Issue number8
DOIs
Publication statusPublished - 13 Mar 2017

Keywords

  • Alzheimer's disease
  • HuperTacrines
  • Huperzin
  • Synthesis
  • Tacrine

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