4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3- d ]pyrimidin-7-(8 H)-ones as BCR kinase inhibitors for B lymphoid malignancies

Raimon Puig De La Bellacasa, Gaël Roué, Patricia Balsas, Patricia Pérez-Galán, Jordi Teixidó, Dolors Colomer, José I. Borrell

Research output: Indexed journal article Articlepeer-review

21 Citations (Scopus)

Abstract

A new family of 4-aminopyrido[2,3-d]pyrimidines active against non-Hodgkin's lymphomas (NHLs) is described. Among these compounds, 19 inhibits the most upstream tyrosine kinases in the B cell receptor (BCR) signaling pathway which are involved in the mature B cell neoplasms. Thus, 19 showed antiproliferative activity at 24 h and 48 h against a panel of 20 NHLs cell lines with GI50 ranging from 1.3 to 6.9 Î.

Original languageEnglish
Pages (from-to)664-675
Number of pages12
JournalEuropean Journal of Medicinal Chemistry
Volume86
DOIs
Publication statusPublished - 30 Oct 2014

Keywords

  • 7-oxopyrido[2,3-d]pyrimidines
  • B-cell receptor
  • Kinases
  • Non-Hodgkin's lymphomas
  • Small molecule inhibitor

Fingerprint

Dive into the research topics of '4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3- d ]pyrimidin-7-(8 H)-ones as BCR kinase inhibitors for B lymphoid malignancies'. Together they form a unique fingerprint.

Cite this