This paper presents the English adaptation of the Multivariable Multiaxial Suggestibility Inventory-2 (MMSI-2), a questionnaire developed specifically for psychological assessment and prediction of anomalous phenomena. The sample consisted of 613 respondents from England (47.6% were women and 52.4% men). All of them were of legal age (mean = 34.5; standard deviation = 8.15). An exploratory factor analysis was applied, and three confirmatory factor models were adjusted. Omega coefficients and test-retest designs were used for reliability analysis. The MMSI-2 has a valid internal structure consisting of five macrofactors: Clinical Personality Tendencies (CPT), Anomalous Perceived Phenomena (APP), Incoherent Manipulations (IMA), Altered States of Consciousness (ASC), and Openness (OP). Omega coefficients for CPT and OP factors were low but acceptable. Furthermore, test-retest trials were excellent for all scales and factors. The psychological factors CPT, IMA, and ASC predicted 18.3% of the variance of anomalous experiences (APP). The authors concluded the English MMSI-2 was a valid and reliable test for the evaluation of anomalous phenomena but recommend that subsequent research reviews the predictive quality of the underlying model.