TY - JOUR
T1 - Triphenylphosphonium cation
T2 - A valuable functional group for antimicrobial photodynamic therapy
AU - Bresolí-Obach, Roger
AU - Gispert, Ignacio
AU - Peña, Diego G.
AU - Boga, Sonia
AU - Gulias, Óscar
AU - Agut, Montserrat
AU - Vázquez, M. Eugenio
AU - Nonell, Santi
N1 - Funding Information:
information Consellera de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (ES), Grant/Award Number: ED431G/09; Fundación Asociación Española contra el Cáncer, Grant/Award Number: IDEAS197VAZQ; Generalitat de Catalunya, Grant/Award Number: 2017 FI_B2 00140; Ministerio de Economía y Competitividad, Grant/Award Numbers: CTQ2013-49317-EXP, CTQ2013-48767-C3-1-R, CTQ2015-71896-REDT, CTQ2015-70698-R, CTQ2016-78454-C2-1-RThis work has been supported by grants CTQ2013-49317-EXP, CTQ2013-48767-C3-1-R, CTQ2015-71896-REDT, CTQ2015-70698-R and CTQ2016-78454-C2-1-R from the Spanish Ministerio de Economía y Competitividad, R.B.-O. thanks the European Social Funds and the SUR del DEC de la Generalitat de Catalunya for a predoctoral fellowship (2017 FI_B2 00140). Financial support from the Xunta de Galicia (Centro singular de investigación de Galicia accreditation 2016-2019, ED431G/09) and the European Union (European Regional Development Fund—ERDF), is gratefully acknowledged. We finally wish to thank the Fundación AECC for their generous support (IDEAS197VAZQ).
Funding Information:
This work has been supported by grants CTQ2013-49317-EXP, CTQ2013-48767-C3-1-R, CTQ2015-71896-REDT, CTQ2015-70698-R and CTQ2016-78454-C2-1-R from the Spanish Ministerio de Economía y Competitividad, R.B.-O. thanks the European Social Funds and the SUR del DEC de la Generalitat de Catalunya for a predoctoral fellowship (2017 FI_B2 00140). Financial support from the Xunta de Galicia (Centro singular de investigación de Galicia accreditation 2016-2019, ED431G/09) and the European Union (European Regional Development Fund—ERDF), is gratefully acknowledged. We finally wish to thank the Fundación AECC for their generous support (IDEAS197VAZQ).
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/10
Y1 - 2018/10
N2 - Light-mediated killing of pathogens by cationic photosensitisers is a promising antimicrobial approach that avoids the development of resistance inherent to the use of antimicrobials. In this study, we demonstrate that modification of different photosensitisers with the triphenylphosphonium cation yields derivatives with excellent photoantimicrobial activity against Gram-positive bacteria (ie, Staphylococcus aureus and Enterococcus faecalis). Thus, the triphenylphosphonium functional group should be considered for the development of photoantimicrobials for the selective killing of Gram-positive bacteria in the presence of Gram-negative species.
AB - Light-mediated killing of pathogens by cationic photosensitisers is a promising antimicrobial approach that avoids the development of resistance inherent to the use of antimicrobials. In this study, we demonstrate that modification of different photosensitisers with the triphenylphosphonium cation yields derivatives with excellent photoantimicrobial activity against Gram-positive bacteria (ie, Staphylococcus aureus and Enterococcus faecalis). Thus, the triphenylphosphonium functional group should be considered for the development of photoantimicrobials for the selective killing of Gram-positive bacteria in the presence of Gram-negative species.
KW - antibiotic resistance
KW - antimicrobial photodynamic therapy
KW - cationic photosensitisers
KW - phenalenone
KW - photoantimicrobials
KW - reactive oxygen species
KW - singlet oxygen
KW - triphenylphosphonium
UR - http://www.scopus.com/inward/record.url?scp=85050607476&partnerID=8YFLogxK
U2 - 10.1002/jbio.201800054
DO - 10.1002/jbio.201800054
M3 - Letter
C2 - 29882394
AN - SCOPUS:85050607476
SN - 1864-063X
VL - 11
JO - Journal of Biophotonics
JF - Journal of Biophotonics
IS - 10
M1 - e201800054
ER -