Triphenylphosphonium cation: A valuable functional group for antimicrobial photodynamic therapy

Roger Bresolí-Obach, Ignacio Gispert, Diego G. Peña, Sonia Boga, Óscar Gulias, Montserrat Agut, M. Eugenio Vázquez, Santi Nonell

Producción científica: Artículo en revista indizadaCartarevisión exhaustiva

20 Citas (Scopus)

Resumen

Light-mediated killing of pathogens by cationic photosensitisers is a promising antimicrobial approach that avoids the development of resistance inherent to the use of antimicrobials. In this study, we demonstrate that modification of different photosensitisers with the triphenylphosphonium cation yields derivatives with excellent photoantimicrobial activity against Gram-positive bacteria (ie, Staphylococcus aureus and Enterococcus faecalis). Thus, the triphenylphosphonium functional group should be considered for the development of photoantimicrobials for the selective killing of Gram-positive bacteria in the presence of Gram-negative species.

Idioma originalInglés
Número de artículoe201800054
PublicaciónJournal of Biophotonics
Volumen11
N.º10
DOI
EstadoPublicada - oct 2018

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