Triphenylphosphonium cation: A valuable functional group for antimicrobial photodynamic therapy

Roger Bresolí-Obach, Ignacio Gispert, Diego G. Peña, Sonia Boga, Óscar Gulias, Montserrat Agut, M. Eugenio Vázquez, Santi Nonell

Research output: Indexed journal article Letterpeer-review

19 Citations (Scopus)

Abstract

Light-mediated killing of pathogens by cationic photosensitisers is a promising antimicrobial approach that avoids the development of resistance inherent to the use of antimicrobials. In this study, we demonstrate that modification of different photosensitisers with the triphenylphosphonium cation yields derivatives with excellent photoantimicrobial activity against Gram-positive bacteria (ie, Staphylococcus aureus and Enterococcus faecalis). Thus, the triphenylphosphonium functional group should be considered for the development of photoantimicrobials for the selective killing of Gram-positive bacteria in the presence of Gram-negative species.

Original languageEnglish
Article numbere201800054
JournalJournal of Biophotonics
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2018

Keywords

  • antibiotic resistance
  • antimicrobial photodynamic therapy
  • cationic photosensitisers
  • phenalenone
  • photoantimicrobials
  • reactive oxygen species
  • singlet oxygen
  • triphenylphosphonium

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