PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

Raúl Cosialls, Cristina Simó, Salvador Borrós, Vanessa Gómez-Vallejo, Claudia Schmidt, Jordi Llop, Ana B. Cuenca, Angela Casini

Research output: Indexed journal article Articlepeer-review

8 Citations (Scopus)

Abstract

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

Original languageEnglish
Article numbere202202604
Number of pages8
JournalChemistry - A European Journal
Volume29
Issue number3
Early online dateNov 2022
DOIs
Publication statusPublished - 12 Jan 2023

Keywords

  • PET imaging
  • ammonium trifluoroborates
  • cisplatin
  • drug delivery
  • metallacages
  • self-assembly

Fingerprint

Dive into the research topics of 'PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery'. Together they form a unique fingerprint.

Cite this