@article{ce10c82629984a43ad14108c84b9a33b,
title = "PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery",
abstract = "To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.",
keywords = "PET imaging, ammonium trifluoroborates, cisplatin, drug delivery, metallacages, self-assembly",
author = "Ra{\'u}l Cosialls and Cristina Sim{\'o} and Salvador Borr{\'o}s and Vanessa G{\'o}mez-Vallejo and Claudia Schmidt and Jordi Llop and Cuenca, {Ana B.} and Angela Casini",
note = "Funding Information: This work was funded by MICINN (PID2020-113661GB-I00) and AGAUR (2017 SGR 01051 and 2017 SGR 00294). Mr A. Lliber{\'i}a and Mss M. Artigues are acknowledged for recording the HR-ESI-MS data for the cage-cisplatin complexes. Support from TUM Innovation Network “Artificial Intelligence Powered Multifunctional Meterials Design” (ARTEMIS) is gratefully acknowledged. Part of the work was supported by MCIN/AEI/10.13039/501100011033 (PID2020-117656RB-I00). Open Access funding enabled and organized by Projekt DEAL. Funding Information: This work was funded by MICINN (PID2020‐113661GB‐I00) and AGAUR (2017 SGR 01051 and 2017 SGR 00294). Mr A. Lliber{\'i}a and Mss M. Artigues are acknowledged for recording the HR‐ESI‐MS data for the cage‐cisplatin complexes. Support from TUM Innovation Network “Artificial Intelligence Powered Multifunctional Meterials Design” (ARTEMIS) is gratefully acknowledged. Part of the work was supported by MCIN/AEI/10.13039/501100011033 (PID2020‐117656RB‐I00). Open Access funding enabled and organized by Projekt DEAL. Publisher Copyright: {\textcopyright} 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.",
year = "2023",
month = jan,
day = "12",
doi = "10.1002/chem.202202604",
language = "English",
volume = "29",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "3",
}