TY - JOUR
T1 - PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery
AU - Cosialls Menárguez, Raúl
AU - Simó, Cristina
AU - Borrós, Salvador
AU - Gómez-Vallejo, Vanessa
AU - Schmidt, Claudia
AU - Llop, Jordi
AU - Cuenca, Ana B.
AU - Casini, Angela
N1 - Publisher Copyright:
© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
PY - 2023/1/12
Y1 - 2023/1/12
N2 - To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.
AB - To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.
KW - PET imaging
KW - ammonium trifluoroborates
KW - cisplatin
KW - drug delivery
KW - metallacages
KW - self-assembly
UR - http://www.scopus.com/inward/record.url?scp=85142294018&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000889062000001&DestLinkType=FullRecord&DestApp=WOS_CPL
UR - http://hdl.handle.net/20.500.14342/4695
U2 - 10.1002/chem.202202604
DO - 10.1002/chem.202202604
M3 - Article
C2 - 36239701
AN - SCOPUS:85142294018
SN - 0947-6539
VL - 29
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 3
M1 - e202202604
ER -