NanoSOSG: A Nanostructured Fluorescent Probe for the Detection of Intracellular Singlet Oxygen

Rubén Ruiz-González, Roger Bresolí-Obach, Òscar Gulías, Montserrat Agut, Huguette Savoie, Ross W. Boyle, Santi Nonell, Francesca Giuntini

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Resum

A biocompatible fluorescent nanoprobe for singlet oxygen (1O2) detection in biological systems was designed, synthesized, and characterized, that circumvents many of the limitations of the molecular probe Singlet Oxygen Sensor Green® (SOSG). This widely used commercial singlet oxygen probe was covalently linked to a polyacrylamide nanoparticle core using different architectures to optimize the response to 1O2. In contrast to its molecular counterpart, the optimum SOSG-based nanoprobe, which we call NanoSOSG, is readily internalized by E. coli cells and does not interact with bovine serum albumin. Furthermore, the spectral characteristics do not change inside cells, and the probe responds to intracellularly generated 1O2 with an increase in fluorescence.

Idioma originalAnglès
Pàgines (de-a)2885-2888
Nombre de pàgines4
RevistaAngewandte Chemie - International Edition
Volum56
Número11
DOIs
Estat de la publicacióPublicada - 6 de març 2017

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