@article{d5f9489df9eb4f0bbe51673b7a53d9f8,
title = "NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging",
abstract = "An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.",
keywords = "fluorescent nanoprobe, multiphoton excitation, singlet oxygen",
author = "Zanocco, {Renzo P.} and Roger Bresol{\'i}-Obach and Francisco N{\'a}jera and Ezequiel P{\'e}rez-Inestrosa and Zanocco, {Antonio L.} and Else Lemp and Santi Nonell",
note = "Funding Information: This research was funded by the Spanish Ministerio de Econom{\'i}a y Competitividad (grant number CTQ2016-78454-C2-1-R) and the Agencia Estatal de Investigaci{\'o}n and FEDER (grant numbers PID2019-104293GB-I00 and PID2020-115801RB-C22), Chilean Agencia Nacional de Investigaci{\'o}n y Desarrollo (FONDECYT-Postdoctoral grant 3190627), and by the Chilean National Commission for Scientific and Technological Research (CONICYT; grant FONDECYT 1150210). R.P.Z. thanks CONICYT for his Ph.D. scholarship Nº 2012831739. R.B.-O. thanks the Agencia Estatal de Investigaci{\'o}n for a Ramon y Cajal contract (RYC2021-032773-I). S.N. thanks the Departament de Recerca i Universitats de la Generalitat de Catalunya for the support given to our research group (2021 SGR 01023) and the ICREA—Catalan Institution for Research and Advanced Studies for grant No. Ac2232308. Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
month = may,
day = "9",
doi = "10.3390/s23104603",
language = "English",
volume = "23",
journal = "Sensors (Switzerland)",
issn = "1424-8220",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",
}