NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

Renzo P. Zanocco; Roger Bresolí-Obach; Francisco Nájera; Ezequiel Pérez-Inestrosa; Antonio L. Zanocco; Else Lemp; Santi Nonell

doi:10.3390/s23104603

NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

Renzo P. Zanocco^*, Roger Bresolí-Obach, Francisco Nájera, Ezequiel Pérez-Inestrosa, Antonio L. Zanocco, Else Lemp, Santi Nonell^*

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

4 Citations (Scopus)

Abstract

An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.

Original language	English
Article number	4603
Number of pages	13
Journal	Sensors (Switzerland)
Volume	23
Issue number	10
DOIs	https://doi.org/10.3390/s23104603
Publication status	Published - 9 May 2023

Keywords

fluorescent nanoprobe
multiphoton excitation
singlet oxygen

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10.3390/s23104603Licence: CC BY

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title = "NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging",

abstract = "An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.",

keywords = "fluorescent nanoprobe, multiphoton excitation, singlet oxygen",

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year = "2023",

month = may,

day = "9",

doi = "10.3390/s23104603",

language = "English",

volume = "23",

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TY - JOUR

T1 - NanoFN10

T2 - A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

AU - Zanocco, Renzo P.

AU - Bresolí-Obach, Roger

AU - Nájera, Francisco

AU - Pérez-Inestrosa, Ezequiel

AU - Zanocco, Antonio L.

AU - Lemp, Else

AU - Nonell, Santi

PY - 2023/5/9

Y1 - 2023/5/9

N2 - An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.

AB - An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.

KW - fluorescent nanoprobe

KW - multiphoton excitation

KW - singlet oxygen

UR - http://www.scopus.com/inward/record.url?scp=85160437602&partnerID=8YFLogxK

UR - http://hdl.handle.net/20.500.14342/4662

U2 - 10.3390/s23104603

DO - 10.3390/s23104603

M3 - Article

AN - SCOPUS:85160437602

SN - 1424-8220

VL - 23

JO - Sensors (Switzerland)

JF - Sensors (Switzerland)

IS - 10

M1 - 4603

ER -

NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

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