NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

Renzo P. Zanocco, Roger Bresolí-Obach, Francisco Nájera, Ezequiel Pérez-Inestrosa, Antonio L. Zanocco, Else Lemp, Santi Nonell

Research output: Indexed journal article Articlepeer-review

1 Citation (Scopus)

Abstract

An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.

Original languageEnglish
Article number4603
Number of pages13
JournalSensors (Switzerland)
Volume23
Issue number10
DOIs
Publication statusPublished - 9 May 2023

Keywords

  • fluorescent nanoprobe
  • multiphoton excitation
  • singlet oxygen

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