BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Maria C. Lucana; Fabien Gosselet; Cristina Díaz-Perlas; Benjamí Oller-Salvia; Roberta  Lucchi

doi:10.1039/d3cb00194f

BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Maria C. Lucana, Fabien Gosselet, Cristina Díaz-Perlas^*, Benjamí Oller-Salvia^*, Roberta Lucchi

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article › Avaluat per experts

3 Cites (Scopus)

Resum

Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.

Idioma original	Anglès
Pàgines (de-a)	7-11
Nombre de pàgines	5
Revista	RSC Chemical Biology
Volum	5
Número	1
DOIs	https://doi.org/10.1039/d3cb00194f
Estat de la publicació	Publicada - de gen. 2024

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10.1039/d3cb00194fLlicència: CC BY

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title = "BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium",

abstract = "Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.",

keywords = "Shuttle peptides, Barrier, Antibodies, Selection",

author = "Lucana, {Maria C.} and Fabien Gosselet and Cristina D{\'i}az-Perlas and Benjam{\'i} Oller-Salvia and Roberta Lucchi",

note = "Publisher Copyright: {\textcopyright} 2024 RSC.",

year = "2024",

month = jan,

doi = "10.1039/d3cb00194f",

language = "English",

volume = "5",

pages = "7--11",

journal = "RSC Chemical Biology",

issn = "2633-0679",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

AU - Lucana, Maria C.

AU - Gosselet, Fabien

AU - Díaz-Perlas, Cristina

AU - Oller-Salvia, Benjamí

AU - Lucchi, Roberta

PY - 2024/1

Y1 - 2024/1

N2 - Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.

AB - Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.

KW - Shuttle peptides

KW - Barrier

KW - Antibodies

KW - Selection

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UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:001119537600001&DestLinkType=FullRecord&DestApp=WOS_CPL

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DO - 10.1039/d3cb00194f

M3 - Article

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AN - SCOPUS:85179614776

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VL - 5

SP - 7

EP - 11

JO - RSC Chemical Biology

JF - RSC Chemical Biology

IS - 1

ER -

BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

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