TY - JOUR
T1 - BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium
AU - Lucana, Maria C.
AU - Lucchi, Roberta
AU - Gosselet, Fabien
AU - Díaz-Perlas, Cristina
AU - Oller-Salvia, Benjamí
N1 - Publisher Copyright:
© 2024 RSC.
PY - 2023
Y1 - 2023
N2 - Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.
AB - Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.
UR - http://www.scopus.com/inward/record.url?scp=85179614776&partnerID=8YFLogxK
U2 - 10.1039/d3cb00194f
DO - 10.1039/d3cb00194f
M3 - Article
AN - SCOPUS:85179614776
SN - 2633-0679
JO - RSC Chemical Biology
JF - RSC Chemical Biology
ER -