TY - JOUR
T1 - Bacteriophobic Zwitterionic/Dopamine Coatings for Medical Elastomers
AU - Texidó, Robert
AU - Cabanach, Pol
AU - Kaplan, Richard
AU - García-Bonillo, Cristina
AU - Pérez, Darío
AU - Zhang, Shuo
AU - Borrós, Salvador
AU - Pena-Francesch, Abdon
N1 - Funding Information:
The authors thank the Generalitat de Catalunya for the Research Consolidated Group Grant (2017 SGR 1559) to Grup d'Enginyeria de Materials (GEMAT) and the University of Michigan College of Engineering for startup funds.
Publisher Copyright:
© 2022 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.
PY - 2022/10/21
Y1 - 2022/10/21
N2 - Despite modern advancements in sterilization and medical practices, bacterial infections remain a significant concern in the implantation of medical devices. There is currently an urgent need for long-lasting and high-stable strategies to avoid the adhesion of bacteria to the wide range of materials present in medical devices. Here, a versatile methodology to create anti-biofouling coatings that prevent the adhesion of bacteria to silicone-based materials used in healthcare is reported. These coatings consist of bifunctional ethylene glycol dimethacrylate as an anchor between a zwitterionic polymer (SBMA), which provides antifouling properties, and a polydopamine layer that operates as an interfacial binder, providing mechanical strength and strong adhesion to elastomeric substrates. The coatings exhibit superhydrophilic and anti-biofouling properties, creating a strong “bacteriophobic effect” that leads to a >99% reduction in bacterial adhesion. This bacteriophobic coating is successfully implemented and validated in a commercial urinary catheter, reducing bacterial adhesion by 1–2 orders of magnitude and avoiding bacterial colonization to prevent catheter-associated urinary tract infections. The results presented here demonstrate the versatility, durability, and scalability of the coating methodology for preventing bacterial adhesion in silicone elastomers, which can be easily applied to other elastomeric materials used in medical devices beyond urinary tract infection prevention.
AB - Despite modern advancements in sterilization and medical practices, bacterial infections remain a significant concern in the implantation of medical devices. There is currently an urgent need for long-lasting and high-stable strategies to avoid the adhesion of bacteria to the wide range of materials present in medical devices. Here, a versatile methodology to create anti-biofouling coatings that prevent the adhesion of bacteria to silicone-based materials used in healthcare is reported. These coatings consist of bifunctional ethylene glycol dimethacrylate as an anchor between a zwitterionic polymer (SBMA), which provides antifouling properties, and a polydopamine layer that operates as an interfacial binder, providing mechanical strength and strong adhesion to elastomeric substrates. The coatings exhibit superhydrophilic and anti-biofouling properties, creating a strong “bacteriophobic effect” that leads to a >99% reduction in bacterial adhesion. This bacteriophobic coating is successfully implemented and validated in a commercial urinary catheter, reducing bacterial adhesion by 1–2 orders of magnitude and avoiding bacterial colonization to prevent catheter-associated urinary tract infections. The results presented here demonstrate the versatility, durability, and scalability of the coating methodology for preventing bacterial adhesion in silicone elastomers, which can be easily applied to other elastomeric materials used in medical devices beyond urinary tract infection prevention.
KW - antibiofouling
KW - bacteriophobic coatings
KW - biopolymer
KW - medical device
KW - medical elastomer
KW - urinary catheter
KW - zwitterionic polymer
UR - http://www.scopus.com/inward/record.url?scp=85137461376&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000851974200001&DestLinkType=FullRecord&DestApp=WOS_CPL
UR - http://hdl.handle.net/20.500.14342/4440
U2 - 10.1002/admi.202201152
DO - 10.1002/admi.202201152
M3 - Article
AN - SCOPUS:85137461376
SN - 2196-7350
VL - 9
JO - Advanced Materials Interfaces
JF - Advanced Materials Interfaces
IS - 30
M1 - 2201152
ER -