TY - JOUR
T1 - Physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease
T2 - A cross-sectional analysis
AU - Delgado-Ortiz, Laura
AU - Arbillaga-Etxarri, Ane
AU - Rodríguez-Chiaradía, Diego A.
AU - Gimeno-Santos, Elena
AU - Barberan-Garcia, Anael
AU - Balcells, Eva
AU - Rodríguez-Roisin, Robert
AU - Garcia-Aymerich, Judith
N1 - Funding Information:
The Urban Training study was funded by grants from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (ISCIII, PI11/01283 and PI14/0419), integrated into Plan Estatal I + D + I 2013–2016 and co-funded by ISCIII-Subdirección General de Evaluación y Fomento de la Investigación and Fondo Europeo de Desarrollo Regional (FEDER); Sociedad Española de Neumología y Cirugía Torácica (SEPAR, 147/2011 and 201/2011), Societat Catalana de Pneumologia (Ajuts al millor projecte en fisioteràpia respiratòria 2013). We acknowledge support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019-2023 Program (CEX2018-000806-S) and the Generalitat de Catalunya through the CERCA Program.
Funding Information:
The Urban Training study was funded by grants from Fondo de Investigaci?n Sanitaria, Instituto de Salud Carlos III (ISCIII, PI11/01283 and PI14/0419), integrated into Plan Estatal I + D + I 2013?2016 and co-funded by ISCIII-Subdirecci?n General de Evaluaci?n y Fomento de la Investigaci?n and Fondo Europeo de Desarrollo Regional (FEDER); Sociedad Espa?ola de Neumolog?a y Cirug?a Tor?cica (SEPAR, 147/2011 and 201/2011), Societat Catalana de Pneumologia (Ajuts al millor projecte en fisioter?pia respirat?ria 2013). We acknowledge support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019-2023 Program (CEX2018-000806-S) and the Generalitat de Catalunya through the CERCA Program.
Publisher Copyright:
© 2021 Elsevier Masson SAS
PY - 2022/5
Y1 - 2022/5
N2 - Background: The cardiac autonomic function in patients with chronic obstructive pulmonary disease (COPD) has been poorly studied. Objectives: We aimed to 1) describe the cardiac autonomic function assessed by heart rate recovery (HRR) and chronotropic response (CR) during a 6-min walk test (6MWT) and afterward and 2) estimate the association of physical activity with HRR and CR in COPD patients. Methods: This cross-sectional analysis included 320 patients with mild to very severe COPD. Physical activity (steps, time in any/moderate-to-vigorous/vigorous physical activity, intensity and sedentary time) was measured during 1 week by accelerometer. CR and HRR were measured during a 6MWT and 5 min after, respectively, and their association with physical activity parameters was estimated by multivariable linear regression models. Results: Patients were 82% male and had a mean (SD) age 68 (8) years, post-bronchodilator FEV1 57 (18) % predicted, and walked a mean of 7716 (4139) steps/day. HRR was slow until 5 min after the 6MWT; the mean (SD) HRR was 15 (10), 22 (11), 25 (12), 25 (12) and 27 (12) bpm after 1, 2, 3, 4 and 5 min, respectively. The mean (SD) CR was 35% (16). After adjusting for relevant confounders, time in vigorous physical activity was significantly associated with a fast decrease in HRR (p = 0.044) and an increase in CR (p = 0.021). We found no independent association for other physical activity parameters. Conclusion: A cardiac autonomic dysfunction is present in patients with mild to very severe COPD and is inversely related to the practice of vigorous physical activity. Trial registration ClinicalTrials.gov NCT01897298.
AB - Background: The cardiac autonomic function in patients with chronic obstructive pulmonary disease (COPD) has been poorly studied. Objectives: We aimed to 1) describe the cardiac autonomic function assessed by heart rate recovery (HRR) and chronotropic response (CR) during a 6-min walk test (6MWT) and afterward and 2) estimate the association of physical activity with HRR and CR in COPD patients. Methods: This cross-sectional analysis included 320 patients with mild to very severe COPD. Physical activity (steps, time in any/moderate-to-vigorous/vigorous physical activity, intensity and sedentary time) was measured during 1 week by accelerometer. CR and HRR were measured during a 6MWT and 5 min after, respectively, and their association with physical activity parameters was estimated by multivariable linear regression models. Results: Patients were 82% male and had a mean (SD) age 68 (8) years, post-bronchodilator FEV1 57 (18) % predicted, and walked a mean of 7716 (4139) steps/day. HRR was slow until 5 min after the 6MWT; the mean (SD) HRR was 15 (10), 22 (11), 25 (12), 25 (12) and 27 (12) bpm after 1, 2, 3, 4 and 5 min, respectively. The mean (SD) CR was 35% (16). After adjusting for relevant confounders, time in vigorous physical activity was significantly associated with a fast decrease in HRR (p = 0.044) and an increase in CR (p = 0.021). We found no independent association for other physical activity parameters. Conclusion: A cardiac autonomic dysfunction is present in patients with mild to very severe COPD and is inversely related to the practice of vigorous physical activity. Trial registration ClinicalTrials.gov NCT01897298.
KW - Autonomic nervous system
KW - Chronic obstructive
KW - Exercise
KW - Heart rate
KW - Pulmonary disease
UR - http://www.scopus.com/inward/record.url?scp=85112762930&partnerID=8YFLogxK
U2 - 10.1016/j.rehab.2021.101501
DO - 10.1016/j.rehab.2021.101501
M3 - Article
C2 - 33662597
AN - SCOPUS:85112762930
SN - 1877-0657
VL - 65
JO - Annals of Physical and Rehabilitation Medicine
JF - Annals of Physical and Rehabilitation Medicine
IS - 3
M1 - 101501
ER -