Viral synthetic peptide interactions with membranes: a monolayer study

P. Sospedra, I. Haro, M. A. Alsina, F. Reig, C. Mestres

Producció científica: Article en revista indexadaArticleAvaluat per experts

13 Cites (Scopus)


A synthetic peptide, corresponding to the 110-121 sequence of VP3-HAV (hepatitis A virus) protein, was synthesized, and its interactions with membrane models were analyzed with monomolecular layer models. Surface activity measurements indicate that the peptide is able to modify the surface activity of water forming monomolecular films. Compression isotherms and penetration kinetics determinations suggest that the hydrophobic moiety of the peptide is able to insert into phospholipidic monolayers promoting an expansion. Moreover, as interactions are stronger with stearylamine-containing monolayers, an electrostatic effect cannot be discarded.

Idioma originalAnglès
Pàgines (de-a)5303-5308
Nombre de pàgines6
Estat de la publicacióPublicada - 3 d’ag. 1999
Publicat externament


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