The Masking Game: Design of Activatable Antibodies and Mimetics for Selective Therapeutics and Cell Control

Roberta Lucchi, Jordi Bentanachs, Benjamí Oller-Salvia

Producció científica: Article en revista indexadaArticleAvaluat per experts

43 Cites (Scopus)

Resum

The high selectivity and affinity of antibody binding have made antibodies all-pervasive tools in therapy, diagnosis, and basic science. A plethora of chemogenetic approaches has been devised to make antibodies responsive to stimuli ranging from light to enzymatic activity, temperature, pH, ions, and effector molecules. Within a single decade, the field of activatable antibodies has yielded marketed therapeutics capable of engaging antigens that could not be targeted with traditional antibodies, as well as new tools to control intracellular protein location and investigate biological processes. Many opportunities remain untapped, waiting for more efficient and generally applicable masking strategies to be developed at the interface between chemistry and biotechnology.

Idioma originalAnglès
Pàgines (de-a)724-738
Nombre de pàgines15
RevistaACS Central Science
Volum7
Número5
DOIs
Estat de la publicacióPublicada - 26 de maig 2021

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