Photosensitive EGFR-Targeted Nanocarriers for Combined Photodynamic and Local Chemotherapy

Elena de las Heras, M. Lluïsa Sagristá, Montserrat Agut, Santi Nonell

Producció científica: Article en revista indexadaArticleAvaluat per experts

7 Cites (Scopus)


The major limitation of any cancer therapy lies in the difficulty of precisely controlling the localization of the drug in the tumor cells. To improve this drawback, our study explores the use of actively-targeted chemo-photo-nanocarriers that recognize and bind to epidermal growth factor receptor-overexpressing cells and promote the local on-demand release of the chemotherapeutic agent doxorubicin triggered by light. Our results show that the attachment of high concentrations of doxorubicin to cetuximab-IRDye700DX-mesoporous silica nanoparticles yields efficient and selective photokilling of EGFR-expressing cells mainly through singlet oxygen-induced release of the doxorubicin from the nanocarrier and without any dark toxicity. Therefore, this novel triply functionalized nanosystem is an effective and safe nanodevice for light-triggered on-demand doxorubicin release.

Idioma originalAnglès
Número d’article405
Estat de la publicacióPublicada - de febr. 2022


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