Heart rate and oxygen uptake kinetics obtained from continuous measurements with wearable devices during outdoor walks of patients with COPD

Objective: Continuous physiological measurements during a laboratory-based exercise test can provide physiological biomarkers, such as heart rate (HR) and oxygen uptake (V̇O₂) kinetics, that carry clinically relevant information. In contrast, it is not clear how continuous data generated by wearable devices during daily-life routines could provide meaningful biomarkers. We aimed to determine whether valid HR and V̇O₂ kinetics can be obtained from measurements with wearable devices during outdoor walks in patients with chronic obstructive pulmonary disease (COPD). Methods: HR (Polar Belt) and V̇O₂(METAMAX3B) were measured during 93 physical activity transitions performed by eight patients with COPD during three different outdoor walks (n_tr= 77) and a 6-minute walk test (n_tr= 16). HR and V̇O₂ kinetics were calculated every time a participant started a walk, finished a walk or walked upstairs. HR and V̇O₂ kinetics were considered valid if the response magnitude and model fit were adequate, and model parameters were reliable. Results: Continuous measurements with wearable devices provided valid HR kinetics when COPD patients started or finished (range 63%–100%) the different outdoor walks and valid V̇O₂ kinetics when they finished (range 63%–100%) an outdoor walk. The amount of valid kinetics and kinetic model performance was comparable between outdoor walks and a laboratory-based exercise test (p >.05). Conclusion: We envision that the presented approach could improve telemonitoring applications of patients with COPD by providing regular, unsupervised assessments of HR kinetics during daily-life routines. This could allow to early identify a decline in the patients’ dynamic physiological functioning, physical fitness and/or health status.