Computer-assisted optimization in HPLC

L. G. Sabaté; A. M. Díaz; X. M. Tomás; M. M. Gassiot

doi:10.1093/chromsci/21.10.439

Computer-assisted optimization in HPLC

L. G. Sabaté, A. M. Díaz, X. M. Tomás, M. M. Gassiot

Producció científica: Article en revista indexada › Article › Avaluat per experts

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A program in BASIC is proposed for ‘off-line’ optimization of experimental parameters in HPLC by the Simplex sequential method. The program is modular and permits adaptation of the chromatographic resolution definition to the user’s needs with a minimum of programming knowledge. The program is applied to improve separation of 2,4-dinitrophenylhydrazones of isolated carbonyl compounds in beer. The optimized parameters are: flow, initial methanol concentration, concentration gradient, and initial isocratic time.

Idioma original	Anglès
Pàgines (de-a)	439-443
Nombre de pàgines	5
Revista	Journal of Chromatographic Science
Volum	21
Número	10
DOIs	https://doi.org/10.1093/chromsci/21.10.439
Estat de la publicació	Publicada - d’oct. 1983
Publicat externament	Sí

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title = "Computer-assisted optimization in HPLC",

abstract = "A program in BASIC is proposed for {\textquoteleft}off-line{\textquoteright} optimization of experimental parameters in HPLC by the Simplex sequential method. The program is modular and permits adaptation of the chromatographic resolution definition to the user{\textquoteright}s needs with a minimum of programming knowledge. The program is applied to improve separation of 2,4-dinitrophenylhydrazones of isolated carbonyl compounds in beer. The optimized parameters are: flow, initial methanol concentration, concentration gradient, and initial isocratic time.",

author = "Sabat{\'e}, {L. G.} and D{\'i}az, {A. M.} and Tom{\'a}s, {X. M.} and Gassiot, {M. M.}",

year = "1983",

month = oct,

doi = "10.1093/chromsci/21.10.439",

language = "English",

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pages = "439--443",

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AU - Sabaté, L. G.

AU - Díaz, A. M.

AU - Tomás, X. M.

AU - Gassiot, M. M.

PY - 1983/10

Y1 - 1983/10

N2 - A program in BASIC is proposed for ‘off-line’ optimization of experimental parameters in HPLC by the Simplex sequential method. The program is modular and permits adaptation of the chromatographic resolution definition to the user’s needs with a minimum of programming knowledge. The program is applied to improve separation of 2,4-dinitrophenylhydrazones of isolated carbonyl compounds in beer. The optimized parameters are: flow, initial methanol concentration, concentration gradient, and initial isocratic time.

AB - A program in BASIC is proposed for ‘off-line’ optimization of experimental parameters in HPLC by the Simplex sequential method. The program is modular and permits adaptation of the chromatographic resolution definition to the user’s needs with a minimum of programming knowledge. The program is applied to improve separation of 2,4-dinitrophenylhydrazones of isolated carbonyl compounds in beer. The optimized parameters are: flow, initial methanol concentration, concentration gradient, and initial isocratic time.

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U2 - 10.1093/chromsci/21.10.439

DO - 10.1093/chromsci/21.10.439

M3 - Article

AN - SCOPUS:0020840871

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JO - Journal of Chromatographic Science

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IS - 10

ER -

Computer-assisted optimization in HPLC

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