Validación de la versión en español del Cuestionario de Tos Leicester en niños con fibrosis quística

Antecedentes: Métodos: Resultados: Conclusión: Background: Cystic fibrosis (CF) patients present chronic cough as one of the main symptoms, which has an important effect on quality of life and social relations. Our goal was to validate the Spanish version of the Leicester Cough Questionnaire (LCQ) in a group of children and teenagers with CF. Methods: After adapting to Spanish by standardized translation and retro-translation methodology, a sample of 58 stable CF patients from 7 to 18years were recruited from three CF specialized centers in Spain. The questionnaire was administered twice; the second administration (LCQ₂) was performed between 2-4 weeks later than the first one (LCQ₁), in order to analyse the reliability and validity of the Spanish version. To correlate results with health related quality of life (HRQoL) we used the Cystic Fibrosis Questionnaire-Revised (CFQ-R). Results: Population was composed by 62% male, age 11.7±3.1years and body mass index (BMI) 19±3kg/m². Total scores from LCQ were: LCQ₁ 19 (17.75-21) vs LCQ₂ 19 (16-21) (P=.199). Cronbach's Alpha coefficient was 0.83 for the LCQ_total and for each specific domain was: 0.82 LCQ_physical; 0.74 LCQ_{psychological} and 0.62 LCQ_social. Intraclass correlation coefficient was: 0.69 LCQ_physical; 0.59 LCQ_{psychological}; 0.45 LCQ_social and 0.71 LCQ_total (good reliability). Relations with CFQ-R showed moderated and significant results: for the LCQtotal: respiratory symptom domain r = 0,51 (P<.001) and physical capacity domain r = 0,62 (P<.05). Conclusion: The Spanish version of the Leicester Cough Questionnaire is reliable and valid for children and adolescents with CF and it has good relations with health related quality of life in this population.