Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

Marta Marszalek; Antoni Planas; Teresa Pellicer

Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

Marta Marszalek
, Antoni Planas^*
, Teresa Pellicer

^*Autor/a de correspondencia de este trabajo

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

4 Citas (Scopus)

Resumen

many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

Idioma original	Inglés
Páginas (desde-hasta)	172-178
Número de páginas	7
Publicación	Afinidad
Volumen	71
N.º	567
Estado	Publicada - 1 jul 2014

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abstract = "many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.",

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N2 - many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

AB - many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

KW - Drug targets

KW - Latency

KW - Tuberculosis

KW - Two-component system

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Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

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