Two-Component Coupling of Carbodiimides and Hydrazides Provides Convergent Access to Biologically Active Compounds

Elisabeth T. Hennessy; Maximilian D. Palkowitz; Josep Sauri; Aaron C. Sather

doi:10.1021/acs.orglett.2c02555

Two-Component Coupling of Carbodiimides and Hydrazides Provides Convergent Access to Biologically Active Compounds

Elisabeth T. Hennessy, Maximilian D. Palkowitz, Josep Sauri, Aaron C. Sather

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

4 Citas (Scopus)

Resumen

A novel, convergent synthesis of aminotriazoloquinazolines is reported. These heterocycles are reliably prepared via a "click-like " reaction between readily available aryl carbodiimides and acyl or aryl hydrazides. Such products are of particular interest with respect to their inhibitory activity against the A2A and A2B adenosine receptors, and the title two-component coupling reaction has greatly accelerated the discovery of potent/selective chemical matter in this space.

Idioma original	Inglés
Número de páginas	4
Publicación	Organic Letters
Fecha en línea anticipada	24 ago 2022
DOI	https://doi.org/10.1021/acs.orglett.2c02555
Estado	Publicada - 2 sept 2022
Publicado de forma externa	Sí

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AU - Sauri, Josep

AU - Sather, Aaron C.

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Two-Component Coupling of Carbodiimides and Hydrazides Provides Convergent Access to Biologically Active Compounds

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