Time-resolved near infrared studies on singlet oxygen production by the photosensitizing 2-arylpropionic acids

Daniel De La Peña, Cristina Martí, Santi Nonell, Luis A. Martínez, Miguel A. Miranda

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva

50 Citas (Web of Science)

Resumen

Time-resolved near infrared emission studies have been carried out on a series of nonsteroidal anti inflammatory 2-arylpropionic acids, in order to assess their ability to photosensitize the production of singlet molecular oxygen O2(1Δ(g)). Benoxaprofen, naproxen, tiaprofenic acid, suprafen, ketoprofen and carprofen showed quantum yields for this process (Φ(Δ)) in the range 0.2-0.7 in acetonitrile. Deprotonation of the propionic acid moiety in mixtures of acetonitrile-ethanol (4:1) basified with KOH produced a systematic decrease in Φ(Δ) for all compounds with the exception of naproxen. This effect was even more dramatic in D2O-based phosphate buffer, where no singlet oxygen could be detected for benoxaprofen, ketoprofen or carprofen. The above results are consistent with the occurrence of competing photochemical reactions of 2-arylpropionic acids in different media and particularly with the enhanced photodecarboxylation from the carboxylate anions.

Idioma originalInglés
Páginas (desde-hasta)828-832
Número de páginas5
PublicaciónPhotochemistry and Photobiology
Volumen65
N.º5
DOI
EstadoPublicada - may 1997

Huella

Profundice en los temas de investigación de 'Time-resolved near infrared studies on singlet oxygen production by the photosensitizing 2-arylpropionic acids'. En conjunto forman una huella única.

Citar esto