The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro

Jordan M. Spatz, Marc N. Wein, Jonathan H. Gooi, Yili Qu, Jenna L. Garr, Shawn Liu, Kevin J. Barry, Yuhei Uda, Forest Lai, Christopher Dedic, Mercedes Balcells-Camps, Henry M. Kronenberg, Philip Babij, Paola Divieti Pajevic

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva

227 Citas (Scopus)

Resumen

Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.

Idioma originalInglés
Páginas (desde-hasta)16744-16758
Número de páginas15
PublicaciónJournal of Biological Chemistry
Volumen290
N.º27
DOI
EstadoPublicada - 3 jul 2015

Huella

Profundice en los temas de investigación de 'The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro'. En conjunto forman una huella única.

Citar esto