The Retro-Aza-Michael Reaction: How Process Optimization Led to New Scientific Insights

B. Ravasio, F. Carrión, R. Nomen, J. Sempere

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva


The synthesis of 2-(2-methylaminoethyl)pyridine from the reaction between 2-vinylpyridine and methylamine serves as a crucial exploration into the reversibility of the aza-Michael reaction. The results unequivocally demonstrate the notable reversibility inherent in the aza-Michael reaction. This characteristic assumes a pivotal role in fostering heightened selectivity, particularly in the realm of Flow Chemistry, where operating temperatures surpass the typical boiling points of the involved mixtures. A preliminary kinetic model, grounded in first-order reactions, aligns well with the experimental data. Results from microwave and Flow Chemistry allow for an initial approximation of the parameters governing the observed equilibrium, providing a foundational understanding of the reaction dynamics. This insight into the reversibility and kinetic aspects of the aza-Michael reaction contributes to the optimization of conditions for enhanced control and efficiency in synthetic processes, particularly under the unique conditions presented by Flow Chemistry.

Idioma originalInglés
Páginas (desde-hasta)68-73
Número de páginas6
EstadoPublicada - 2024


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