Structure elucidation of uniformly (13)C labeled small molecule natural products

Utilization of H-2, C-13, and N-15 isotopically labeled proteins and peptides is now routine in biomolecular NMR investigations. The wide-spread availability of inexpensive, uniformly C-13 enriched glucose now makes it possible to isolate uniformly C-13 labeled natural products from microbial fermentation. We now wish to describe an approach for the rapid structural characterization of uniformly C-13 labeled natural products that avoids the pitfalls of relying on parameters typically employed in biomolecular NMR studies. Copyright (C) 2015 John Wiley & Sons, Ltd.