Structure elucidation of uniformly (13)C labeled small molecule natural products

Mikhail Reibarkh; Thomas P. Wyche; Josep Sauri; Tim S. Bugni; Gary E. Martin; R. Thomas Williamson

doi:10.1002/mrc.4333

Structure elucidation of uniformly (13)C labeled small molecule natural products

Mikhail Reibarkh, Thomas P. Wyche, Josep Sauri, Tim S. Bugni, Gary E. Martin, R. Thomas Williamson

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

6 Citas (Scopus)

Resumen

Utilization of H-2, C-13, and N-15 isotopically labeled proteins and peptides is now routine in biomolecular NMR investigations. The wide-spread availability of inexpensive, uniformly C-13 enriched glucose now makes it possible to isolate uniformly C-13 labeled natural products from microbial fermentation. We now wish to describe an approach for the rapid structural characterization of uniformly C-13 labeled natural products that avoids the pitfalls of relying on parameters typically employed in biomolecular NMR studies. Copyright (C) 2015 John Wiley & Sons, Ltd.

Idioma original	Inglés
Páginas (desde-hasta)	996-1002
Número de páginas	7
Publicación	Magnetic Resonance in Chemistry
Volumen	53
N.º	12
DOI	https://doi.org/10.1002/mrc.4333
Estado	Publicada - dic 2015
Publicado de forma externa	Sí

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title = "Structure elucidation of uniformly (13)C labeled small molecule natural products",

abstract = "Utilization of H-2, C-13, and N-15 isotopically labeled proteins and peptides is now routine in biomolecular NMR investigations. The wide-spread availability of inexpensive, uniformly C-13 enriched glucose now makes it possible to isolate uniformly C-13 labeled natural products from microbial fermentation. We now wish to describe an approach for the rapid structural characterization of uniformly C-13 labeled natural products that avoids the pitfalls of relying on parameters typically employed in biomolecular NMR studies. Copyright (C) 2015 John Wiley & Sons, Ltd.",

keywords = "C-13-C-13 COSY and COSYLR, Ct-hsqc, U-C-13 labeled, Enterocin, Natural products, Structure elucidation",

author = "Mikhail Reibarkh and Wyche, {Thomas P.} and Josep Sauri and Bugni, {Tim S.} and Martin, {Gary E.} and Williamson, {R. Thomas}",

year = "2015",

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AU - Martin, Gary E.

AU - Williamson, R. Thomas

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KW - U-C-13 labeled

KW - Enterocin

KW - Natural products

KW - Structure elucidation

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Structure elucidation of uniformly (13)C labeled small molecule natural products

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