@article{fab8378f297d4a6f9e0fd7586897f49b,
title = "Selective reduction of the 7-oxo group in pyrido[2,3d]pyrimidine-4,7- diones: A new synthetic approach to 5,10-dideazatetrahydrofolic acid (DDATHF)",
abstract = "A selective reduction of the carbonyl group at C7 with borane in THF is accomplished for 2,4-diamino-7-oxo and 2-amino-4,7-dioxo substituted pyridopyrimidines (7a-c) and (13a-c) respectively, the ester group remaining unaltered in both cases. The synthesis of 21c allows a new synthetic approach to 5,10-dideazatetrahydrofolic acid (DDATHF, 1) because it is a common intermediate in two procedures that afford the aforementioned antifolate.",
keywords = "5,10-dideaza-5,6,7,8-tetrahydrofolic acid, Absolute-configuration, Asymmetric-synthesis, Organic-compounds, Purine synthesis, Folic-acid, Phase-i, Convergent, Diborane, Analogs",
author = "Borrell, {Jos{\'e} I.} and Jordi Teixid{\'o} and Matallana, {Josep Llu{\'i}s} and Blanca Mart{\'i}nez-Teipel and Esther Couceiro",
year = "2000",
month = mar,
day = "1",
doi = "10.3987/com-99-s129",
language = "English",
volume = "52",
pages = "1207--1214",
journal = "Heterocycles",
issn = "0385-5414",
publisher = "Japan Institute of Heterocyclic Chemistry",
number = "3",
}