TY - JOUR
T1 - Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-plus trial
AU - Sánchez-Villegas, Almudena
AU - Álvarez-Pérez, Jacqueline
AU - Toledo, Estefanía
AU - Salas-Salvadó, Jordi
AU - Ortega-Azorín, Carolina
AU - Zomeño, Maria Dolores
AU - Vioque, Jesús
AU - Martínez, Jose Alfredo
AU - Romaguera, Dora
AU - Pérez-López, Jessica
AU - López-Miranda, José
AU - Estruch, Ramón
AU - Bueno-Cavanillas, Aurora
AU - Arós, Fernando
AU - Tur, Josep A.
AU - Tinahones, Francisco J.
AU - Lecea, Oscar
AU - Martín, Vicente
AU - Ortega-Calvo, M.
AU - Vázquez, Clotilde
AU - Pintó, Xavier
AU - Vidal, Josep
AU - Daimiel, Lidia
AU - Delgado-Rodríguez, Miguel
AU - Matía, Pilar
AU - Corella, Dolores
AU - Díaz-López, Andrés
AU - Babio, Nancy
AU - Muñoz, Miguel Ángel
AU - Fitó, Montserrat
AU - de la Hera, Manoli García
AU - Abete, Itziar
AU - García-Rios, Antonio
AU - Ros, Emilio
AU - Ruíz-Canela, Miguel
AU - Martínez-González, Miguel Ángel
AU - Izquierdo, Marisol
AU - Serra-Majem, Lluis
N1 - Funding Information:
Funding: This research was funded by the Spanish Ministry of Health (Carlos III Health Institute) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (grant numbers and corresponding codes: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14-00696, PI14/01206, PI14/01919, PI14/00853), the European Research Council (Advanced Research Grant 2013–2018; 340918) grant to MAMG, the Recercaixa grant to J. S-S. and NB (2013ACUP00194), the grant from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016), the SEMERGEN grant, and FEDER funds (CB06/03).
Funding Information:
This research was funded by the Spanish Ministry of Health (Carlos III Health Institute) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (grant numbers and corresponding codes: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14-00696, PI14/01206, PI14/01919, PI14/00853), the European Research Council (Advanced Research Grant 2013–2018; 340918) grant to MAMG, the Recercaixa grant to J. S-S. and NB (2013ACUP00194), the grant from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016), the SEMERGEN grant, and FEDER funds (CB06/03).
Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/12/18
Y1 - 2018/12/18
N2 - Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63–0.94), 0.71 (0.58–0.87), and 0.78 (0.64–0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5–1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
AB - Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63–0.94), 0.71 (0.58–0.87), and 0.78 (0.64–0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5–1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
KW - Depression
KW - Docosahexaenoic acid
KW - Eicosapentaenoic acid
KW - Fish
KW - Omega-3
UR - https://www.scopus.com/pages/publications/85058901912
U2 - 10.3390/nu10122000
DO - 10.3390/nu10122000
M3 - Article
C2 - 30567286
AN - SCOPUS:85058901912
SN - 2072-6643
VL - 10
JO - Nutrients
JF - Nutrients
IS - 12
M1 - 2000
ER -