TY - JOUR
T1 - Recent Photosensitizer Developments, Delivery Strategies and Combination-based Approaches for Photodynamic Therapy†
AU - Mariño-Ocampo, Nory
AU - Dibona-Villanueva, Luciano
AU - Escobar-Álvarez, Elizabeth
AU - Guerra-Díaz, Daniel
AU - Zúñiga-Núñez, Daniel
AU - Fuentealba, Denis
AU - Robinson-Duggon, José
N1 - Publisher Copyright:
© 2022 American Society for Photobiology.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Photodynamic therapy of cancer (PDT) is a therapeutic technique, minimally invasive, which is currently used to treat cancerous lesions and tumors that have been in the spotlight for its potential over the recent decades. Nonetheless, PDT still needs further development to become a first-option treatment for patients. This review compiles recent progress in several aspects of the current research in the constantly growing area of PDT to overcome the main challenges as an attempt to serve as a guide and reference for newcomers into this research area. This review has been prepared to highlight the use of chemical modifications on photosensitizers to improve their solubility, photostability, selectivity and phototoxicity. Additionally, the use of liposomes and cavitands as drug delivery systems to aid in the biodistribution and bioaccumulation of photosensitizers is presented. Also, the combination of PDT with chemotherapy or immunotherapy as an option to boost and improve treatment outcomes is discussed. Finally, the inhibition of antioxidant enzymes as a strategy for a synergistic effect to ameliorate the performance of the photosensitizers in PDT is presented as an alternative for future researchers.
AB - Photodynamic therapy of cancer (PDT) is a therapeutic technique, minimally invasive, which is currently used to treat cancerous lesions and tumors that have been in the spotlight for its potential over the recent decades. Nonetheless, PDT still needs further development to become a first-option treatment for patients. This review compiles recent progress in several aspects of the current research in the constantly growing area of PDT to overcome the main challenges as an attempt to serve as a guide and reference for newcomers into this research area. This review has been prepared to highlight the use of chemical modifications on photosensitizers to improve their solubility, photostability, selectivity and phototoxicity. Additionally, the use of liposomes and cavitands as drug delivery systems to aid in the biodistribution and bioaccumulation of photosensitizers is presented. Also, the combination of PDT with chemotherapy or immunotherapy as an option to boost and improve treatment outcomes is discussed. Finally, the inhibition of antioxidant enzymes as a strategy for a synergistic effect to ameliorate the performance of the photosensitizers in PDT is presented as an alternative for future researchers.
UR - http://www.scopus.com/inward/record.url?scp=85144251265&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000900038900001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1111/php.13749
DO - 10.1111/php.13749
M3 - Review
C2 - 36434770
AN - SCOPUS:85144251265
SN - 0031-8655
VL - 99
SP - 469
EP - 497
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
IS - 2
ER -