Pyrido[2,3-d]pyrimidin-7(8H)-ones: synthesis and biomedical applications

Producción científica: Artículo en revista indizadaRecensiónrevisión exhaustiva

26 Citas (Scopus)

Resumen

Pyrido[2,3-d]pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-d]pyrimidine-7(8H)-ones (2) due to the similitude with nitrogen bases present in DNA and RNA. Currently there are more than 20,000 structures 2 described which correspond to around 2900 references (half of them being patents). Furthermore, the number of references containing compounds of general structure 2 have increased almost exponentially in the last 10 years. The present review covers the synthetic methods used for the synthesis of pyrido[2,3-d]pyrimidine-7(8H)-ones (2), both starting from a preformed pyrimidine ring or a pyridine ring, and the biomedical applications of such compounds.

Idioma originalInglés
Número de artículo4161
PublicaciónMolecules
Volumen24
N.º22
DOI
EstadoPublicada - 16 nov 2019

Huella

Profundice en los temas de investigación de 'Pyrido[2,3-d]pyrimidin-7(8H)-ones: synthesis and biomedical applications'. En conjunto forman una huella única.

Citar esto