Physicochemical interaction of opioid peptides with phospholipids and membranes

M. A. Alsina; N. Solé; C. Mestres; M. A. Busquets; I. Haro; J. M.Garcia Antón

doi:10.1016/0378-5173(91)90170-S

Physicochemical interaction of opioid peptides with phospholipids and membranes

M. A. Alsina
, N. Solé
, C. Mestres
, M. A. Busquets
, I. Haro
, J. M.Garcia Antón^*

^*Autor/a de correspondencia de este trabajo

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

8 Citas (Scopus)

Resumen

The surface activity and opioid potency of peptide analogues of enkephalins are described. The molecules under study have as a general formula: Tyr-D · Met-Gly-Phe-Pro-NH-(CH₂)_n-CH₃, n being 5, 9 or 13. The interaction of these peptide-alkylamides with PC, PS, PI and GM₁ monolayers and their opioid activity measured by the GPI (guinea pig ileum) test are highly dependent on the hydrophobicity of the molecule. Moreover, the GPI muscle contraction records show a strong hydrophobic interaction between the peptides and the bilayer components, that holds the molecules anchored to the membrane and increases the duration of the effect.

Idioma original	Inglés
Páginas (desde-hasta)	111-117
Número de páginas	7
Publicación	International Journal of Pharmaceutics
Volumen	70
N.º	1-2
DOI	https://doi.org/10.1016/0378-5173(91)90170-S
Estado	Publicada - 31 mar 1991
Publicado de forma externa	Sí

Acceder al documento

10.1016/0378-5173(91)90170-S

Otros archivos y enlaces

Enlace a la publicación en Scopus

Cómo citar

@article{cc73938e5ba948a5814079fb472170e7,

title = "Physicochemical interaction of opioid peptides with phospholipids and membranes",

abstract = "The surface activity and opioid potency of peptide analogues of enkephalins are described. The molecules under study have as a general formula: Tyr-D · Met-Gly-Phe-Pro-NH-(CH2)n-CH3, n being 5, 9 or 13. The interaction of these peptide-alkylamides with PC, PS, PI and GM1 monolayers and their opioid activity measured by the GPI (guinea pig ileum) test are highly dependent on the hydrophobicity of the molecule. Moreover, the GPI muscle contraction records show a strong hydrophobic interaction between the peptides and the bilayer components, that holds the molecules anchored to the membrane and increases the duration of the effect.",

keywords = "Cholesterol, Compression isotherm, Ganglioside, Monolayer, Naloxone, Penetration kinetics, Peptide, Phospholipid",

author = "Alsina, \{M. A.\} and N. Sol{\'e} and C. Mestres and Busquets, \{M. A.\} and I. Haro and Ant{\'o}n, \{J. M.Garcia\}",

year = "1991",

month = mar,

day = "31",

doi = "10.1016/0378-5173(91)90170-S",

language = "English",

volume = "70",

pages = "111--117",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Physicochemical interaction of opioid peptides with phospholipids and membranes

AU - Alsina, M. A.

AU - Solé, N.

AU - Mestres, C.

AU - Busquets, M. A.

AU - Haro, I.

AU - Antón, J. M.Garcia

PY - 1991/3/31

Y1 - 1991/3/31

N2 - The surface activity and opioid potency of peptide analogues of enkephalins are described. The molecules under study have as a general formula: Tyr-D · Met-Gly-Phe-Pro-NH-(CH2)n-CH3, n being 5, 9 or 13. The interaction of these peptide-alkylamides with PC, PS, PI and GM1 monolayers and their opioid activity measured by the GPI (guinea pig ileum) test are highly dependent on the hydrophobicity of the molecule. Moreover, the GPI muscle contraction records show a strong hydrophobic interaction between the peptides and the bilayer components, that holds the molecules anchored to the membrane and increases the duration of the effect.

AB - The surface activity and opioid potency of peptide analogues of enkephalins are described. The molecules under study have as a general formula: Tyr-D · Met-Gly-Phe-Pro-NH-(CH2)n-CH3, n being 5, 9 or 13. The interaction of these peptide-alkylamides with PC, PS, PI and GM1 monolayers and their opioid activity measured by the GPI (guinea pig ileum) test are highly dependent on the hydrophobicity of the molecule. Moreover, the GPI muscle contraction records show a strong hydrophobic interaction between the peptides and the bilayer components, that holds the molecules anchored to the membrane and increases the duration of the effect.

KW - Cholesterol

KW - Compression isotherm

KW - Ganglioside

KW - Monolayer

KW - Naloxone

KW - Penetration kinetics

KW - Peptide

KW - Phospholipid

UR - https://www.scopus.com/pages/publications/0025908164

U2 - 10.1016/0378-5173(91)90170-S

DO - 10.1016/0378-5173(91)90170-S

M3 - Article

AN - SCOPUS:0025908164

SN - 0378-5173

VL - 70

SP - 111

EP - 117

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Physicochemical interaction of opioid peptides with phospholipids and membranes

Resumen

Acceder al documento

Otros archivos y enlaces

Huella

Cómo citar