TY - JOUR
T1 - Physical activity characteristics across GOLD quadrants depend on the questionnaire used
AU - Demeyer, Heleen
AU - Gimeno-Santos, Elena
AU - Rabinovich, Roberto A.
AU - Hornikx, Miek
AU - Louvaris, Zafeiris
AU - De Boer, Willem I.
AU - Karlsson, Niklas
AU - De Jong, Corina
AU - Van Der Molen, Thys
AU - Vogiatzis, Ioannis
AU - Janssens, Wim
AU - Garcia-Aymerich, Judith
AU - Troosters, Thierry
AU - Polkey, Michael I.
N1 - Publisher Copyright:
© 2016 Demeyer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/3
Y1 - 2016/3
N2 - Background: The GOLD multidimensional classification of COPD severity combines the exacerbation risk with the symptom experience, for which 3 different questionnaires are permitted. This study investigated differences in physical activity (PA) in the different GOLD quadrants and patient's distribution in relation to the questionnaire used. Methods: 136 COPD patients (58±21% FEV1 predicted, 34F/102M) completed COPD assessment test (CAT), clinical COPD questionnaire (CCQ) and modified Medical Research Council (mMRC) questionnaire. Exacerbation history, spirometry and 6MWD were collected. PA was objectively measured for 2 periods of 1 week, 6 months apart, in 5 European centres; to minimise seasonal and clinical variation the average of these two periods was used for analysis. Results: GOLD quadrants C+D had reduced PA compared with A+B (3824 [2976] vs. 5508 [4671] steps.d-1, p<0.0001). The choice of questionnaire yielded different patient distributions (agreement mMRC-CAT k = 0.57; CCQ-mMRC K = 0.71; CCQ-CAT K = 0.72) with different clinical characteristics. PA was notably lower in patients with an mMRC score ≥2 (3430 [2537] vs. 5443 [3776] steps.d-1p <0.001) in both the low and high risk quadrants. Conclusions: Using different questionnaires changes the patient distribution and results in different clinical characteristics. Therefore, standardization of the questionnaire used for classification is critical to allow comparison of different studies using this as an entry criterion.
AB - Background: The GOLD multidimensional classification of COPD severity combines the exacerbation risk with the symptom experience, for which 3 different questionnaires are permitted. This study investigated differences in physical activity (PA) in the different GOLD quadrants and patient's distribution in relation to the questionnaire used. Methods: 136 COPD patients (58±21% FEV1 predicted, 34F/102M) completed COPD assessment test (CAT), clinical COPD questionnaire (CCQ) and modified Medical Research Council (mMRC) questionnaire. Exacerbation history, spirometry and 6MWD were collected. PA was objectively measured for 2 periods of 1 week, 6 months apart, in 5 European centres; to minimise seasonal and clinical variation the average of these two periods was used for analysis. Results: GOLD quadrants C+D had reduced PA compared with A+B (3824 [2976] vs. 5508 [4671] steps.d-1, p<0.0001). The choice of questionnaire yielded different patient distributions (agreement mMRC-CAT k = 0.57; CCQ-mMRC K = 0.71; CCQ-CAT K = 0.72) with different clinical characteristics. PA was notably lower in patients with an mMRC score ≥2 (3430 [2537] vs. 5443 [3776] steps.d-1p <0.001) in both the low and high risk quadrants. Conclusions: Using different questionnaires changes the patient distribution and results in different clinical characteristics. Therefore, standardization of the questionnaire used for classification is critical to allow comparison of different studies using this as an entry criterion.
UR - https://www.scopus.com/pages/publications/84961751356
UR - http://hdl.handle.net/20.500.14342/815
U2 - 10.1371/journal.pone.0151255
DO - 10.1371/journal.pone.0151255
M3 - Article
C2 - 26974332
AN - SCOPUS:84961751356
SN - 1932-6203
VL - 11
JO - PLoS ONE
JF - PLoS ONE
IS - 3
M1 - e0151255
ER -