TY - JOUR
T1 - Physical activity and clinical and functional status in COPD
AU - Garcia-Aymerich, Judith
AU - Serra, Ignasi
AU - Gómez, Federico P.
AU - Farrero, Eva
AU - Balcells, Eva
AU - Rodríguez, Diego A.
AU - De Batlle, Jordi
AU - Gimeno, Elena
AU - Donaire-Gonzalez, David
AU - Orozco-Levi, Mauricio
AU - Sauleda, Jaume
AU - Gea, Joaquim
AU - Rodriguez-Roisin, Robert
AU - Roca, Josep
AU - Agustí, Àlvar G.
AU - Antó, Josep M.
AU - Benet, Marta
AU - Guerra, Stefano
AU - Gayete, Àngel
AU - Vollmer, Ivan
AU - Barbera, Joan Albert
AU - Paré, Carles
AU - Freixa, Xavier
AU - Portillo, Karina
AU - Ferrer, Jaume
AU - Andreu, Jordi
AU - Pallissa, Esther
AU - Rodríguez, Esther
AU - Casan, Pere
AU - Güell, Rosa
AU - Giménez, Ana
AU - Monsó, Eduard
AU - Marín, Alicia
AU - Morera, Josep
AU - Escarrabill, Joan
AU - Ferrer, Antoni
AU - Togores, Bernat
AU - Gáldiz, Juan Bautista
AU - López, Lorena
AU - Belda, José
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Background: The mechanisms underlying the benefits of regular physical activity in the evolution of COPD have not been established. Our objective was to assess the relationship between regular physical activity and the clinical and functional characteristics of COPD. Methods: Three hundred forty-one patients were hospitalized for the first time because of a COPD exacerbation in nine teaching hospitals in Spain. COPD diagnosis was confirmed by spirometry under stable conditions. Physical activity before the first COPD hospitalization was measured using the Yale questionnaire. The following outcome variables were studied under stable conditions: dyspnea, nutritional status, complete lung function tests, respiratory and peripheral muscle strength, bronchial colonization, and systemic inflammation. Results: The mean age was 68 years (SD, 9 years), 93% were men, 43% were current smokers, and the mean postbronchodilator FEV1 was 52% predicted (SD, 16% predicted). Multivariate linear regression models were built separately for each outcome variable and adjusted for potential confounders (including remaining outcomes if appropriate). When patients with the lowest quartile of physical activity were compared to patients in the other quartiles, physical activity was associated with significantly higher diffusing capacity of the lung for carbon monoxide (DLCO) [change in the second, third, and fourth quartiles of physical activity, compared with first quartile (+ 6%, + 6%, and + 9% predicted, respectively; p = 0.012 [for trend])], expiratory muscle strength (maximal expiratory pressure [PEmax]) [+ 7%, + 5%, and + 9% predicted, respectively; p = 0.081], 6-min walking distance (6MWD) [+ 40, + 41, and + 45 m, respectively; p = 0.006 (for trend)], and maximal oxygen uptake (V̇O2peak) [+ 55, + 185, and + 81 mL/min, respectively; p = 0.110 (for trend)]. Similarly, physical activity reduced the risk of having high levels of circulating tumor necrosis factor α (odds ratio, 0.78, 0.61, and 0.36, respectively; p = 0.011) and C-reactive protein (0.70, 0.51, and 0.52, respectively; p = 0.036) in multivariate logistic regression. Conclusions: More physically active COPD patients show better functional status in terms of DLCO, PEmax, 6MWD, V̇O2peak, and systemic inflammation.
AB - Background: The mechanisms underlying the benefits of regular physical activity in the evolution of COPD have not been established. Our objective was to assess the relationship between regular physical activity and the clinical and functional characteristics of COPD. Methods: Three hundred forty-one patients were hospitalized for the first time because of a COPD exacerbation in nine teaching hospitals in Spain. COPD diagnosis was confirmed by spirometry under stable conditions. Physical activity before the first COPD hospitalization was measured using the Yale questionnaire. The following outcome variables were studied under stable conditions: dyspnea, nutritional status, complete lung function tests, respiratory and peripheral muscle strength, bronchial colonization, and systemic inflammation. Results: The mean age was 68 years (SD, 9 years), 93% were men, 43% were current smokers, and the mean postbronchodilator FEV1 was 52% predicted (SD, 16% predicted). Multivariate linear regression models were built separately for each outcome variable and adjusted for potential confounders (including remaining outcomes if appropriate). When patients with the lowest quartile of physical activity were compared to patients in the other quartiles, physical activity was associated with significantly higher diffusing capacity of the lung for carbon monoxide (DLCO) [change in the second, third, and fourth quartiles of physical activity, compared with first quartile (+ 6%, + 6%, and + 9% predicted, respectively; p = 0.012 [for trend])], expiratory muscle strength (maximal expiratory pressure [PEmax]) [+ 7%, + 5%, and + 9% predicted, respectively; p = 0.081], 6-min walking distance (6MWD) [+ 40, + 41, and + 45 m, respectively; p = 0.006 (for trend)], and maximal oxygen uptake (V̇O2peak) [+ 55, + 185, and + 81 mL/min, respectively; p = 0.110 (for trend)]. Similarly, physical activity reduced the risk of having high levels of circulating tumor necrosis factor α (odds ratio, 0.78, 0.61, and 0.36, respectively; p = 0.011) and C-reactive protein (0.70, 0.51, and 0.52, respectively; p = 0.036) in multivariate logistic regression. Conclusions: More physically active COPD patients show better functional status in terms of DLCO, PEmax, 6MWD, V̇O2peak, and systemic inflammation.
UR - http://www.scopus.com/inward/record.url?scp=67650822158&partnerID=8YFLogxK
U2 - 10.1378/chest.08-2532
DO - 10.1378/chest.08-2532
M3 - Article
AN - SCOPUS:67650822158
SN - 0012-3692
VL - 136
SP - 62
EP - 70
JO - Chest
JF - Chest
IS - 1
ER -