Penetration of morphine and naloxone in phosphatidylserine monolayers

F. Reig; C. Mestres; J. M.García Antón; G. Valencia; M. A. Alsina

doi:10.1016/0378-5173(88)90126-3

Penetration of morphine and naloxone in phosphatidylserine monolayers

F. Reig, C. Mestres, J. M.García Antón, G. Valencia, M. A. Alsina^*

^*Autor/a de correspondencia de este trabajo

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

4 Citas (Scopus)

Resumen

The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m^-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m^-1.

Idioma original	Inglés
Páginas (desde-hasta)	269-272
Número de páginas	4
Publicación	International Journal of Pharmaceutics
Volumen	44
N.º	1-3
DOI	https://doi.org/10.1016/0378-5173(88)90126-3
Estado	Publicada - jun 1988
Publicado de forma externa	Sí

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title = "Penetration of morphine and naloxone in phosphatidylserine monolayers",

abstract = "The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.",

keywords = "Adsorption kinetics, Monolayer, Opiate-phospholipid interaction",

author = "F. Reig and C. Mestres and Ant{\'o}n, {J. M.Garc{\'i}a} and G. Valencia and Alsina, {M. A.}",

year = "1988",

month = jun,

doi = "10.1016/0378-5173(88)90126-3",

language = "English",

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T1 - Penetration of morphine and naloxone in phosphatidylserine monolayers

AU - Reig, F.

AU - Mestres, C.

AU - Antón, J. M.García

AU - Valencia, G.

AU - Alsina, M. A.

PY - 1988/6

Y1 - 1988/6

N2 - The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.

AB - The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.

KW - Adsorption kinetics

KW - Monolayer

KW - Opiate-phospholipid interaction

UR - http://www.scopus.com/inward/record.url?scp=0023946334&partnerID=8YFLogxK

U2 - 10.1016/0378-5173(88)90126-3

DO - 10.1016/0378-5173(88)90126-3

M3 - Article

AN - SCOPUS:0023946334

SN - 0378-5173

VL - 44

SP - 269

EP - 272

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-3

ER -

Penetration of morphine and naloxone in phosphatidylserine monolayers

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