Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia

Isabel Saez, Jordi Duran, Christopher Sinadinos, Antoni Beltran, Oscar Yanes, María F. Tevy, Carlos Martínez-Pons, Marco Milán, Joan J. Guinovart

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva

155 Citas (Scopus)

Resumen

Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as well as with genetically modified mice and flies, here we report that-against general belief-neurons contain a low but measurable amount of glycogen. Moreover, we also show that these cells express the brain isoform of glycogen phosphorylase, allowing glycogen to be fully metabolized. Most importantly, we show an active neuronal glycogen metabolism that protects cultured neurons from hypoxia-induced death and flies from hypoxia-induced stupor. Our findings change the current view of the role of glycogen in the brain and reveal that endogenous neuronal glycogen metabolism participates in the neuronal tolerance to hypoxic stress.

Idioma originalInglés
Páginas (desde-hasta)945-955
Número de páginas11
PublicaciónJournal of Cerebral Blood Flow and Metabolism
Volumen34
N.º6
DOI
EstadoPublicada - jun 2014
Publicado de forma externa

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