@article{22ea7101ee484119976ecdf18509d80d,
title = "Maintenance of liver glycogen during long-term fasting preserves energy state in mice",
abstract = "Glycogen shortage during fasting coincides with dramatic changes in hepatic adenine nucleotide levels. The aim of this work was to study the relevance of liver glycogen in the regulation of the hepatic energy state during food deprivation. To this end, we examined the response of mice with sustained increased liver glycogen content to prolonged fasting. In order to increase hepatic glycogen content, we generated mice that overexpress protein targeting to glycogen (PTG) in the liver (PTGOE mice). Control and PTGOE mice were fed ad libitum or fasted for 36 h. Upon fasting, PTGOE mice retained significant hepatic glycogen stores and maintained hepatic energy status. Furthermore, we show that liver glycogen controls insulin sensitivity, gluconeogenesis, lipid metabolism, and ketogenesis upon nutrient deprivation.",
keywords = "AMPK, energy state, fasting, gluconeogenesis, glycogen, liver",
author = "Iliana L{\'o}pez-Soldado and Angelo Bertini and Anna Adrover and Jordi Duran and Guinovart, \{Joan J.\}",
note = "Funding Information: The authors thank Emma Veza, Vanessa Hernandez, and Laura Alcaide for technical assistance. This study was supported by grants from the Spanish MINECO (BFU2017-84345-P), Fundaci{\'o} La Marat{\'o} de TV3 (201613-10), and the CIBER de Diabetes y Enfermedades Metab{\'o}licas Asociadas (ISCIII, Ministerio de Ciencia e Innovaci{\'o}n). None of the supporting agencies had any role in performing the work or in writing the manuscript. IRB Barcelona is recipient of a Severo Ochoa excellence award. Funding Information: The authors thank Emma Veza, Vanessa Hernandez, and Laura Alcaide for technical assistance. This study was supported by grants from the Spanish MINECO (BFU2017‐84345‐P), Fundaci{\'o} La Marat{\'o} de TV3 (201613‐10), and the (ISCIII, ). None of the supporting agencies had any role in performing the work or in writing the manuscript. IRB Barcelona is recipient of a Severo Ochoa excellence award. CIBER de Diabetes y Enfermedades Metab{\'o}licas Asociadas Ministerio de Ciencia e Innovaci{\'o}n Publisher Copyright: {\textcopyright} 2020 Federation of European Biochemical Societies",
year = "2020",
month = jun,
day = "1",
doi = "10.1002/1873-3468.13770",
language = "English",
volume = "594",
pages = "1698--1710",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc",
number = "11",
}