Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model

João Conde, Nuria Oliva, Yi Zhang, Natalie Artzi

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva

375 Citas (Scopus)

Resumen

Conventional cancer therapies involve the systemic delivery of anticancer agents that neither discriminate between cancer and normal cells nor eliminate the risk of cancer recurrence. Here, we demonstrate that the combination of gene, drug and phototherapy delivered through a prophylactic hydrogel patch leads, in a colon cancer mouse model, to complete tumour remission when applied to non-resected tumours and to the absence of tumour recurrence when applied following tumour resection. The adhesive hydrogel patch enhanced the stability and provided local delivery of embedded nanoparticles. Spherical gold nanoparticles were used as a first wave of treatment to deliver siRNAs against Kras, a key oncogene driver, and rod-shaped gold nanoparticles mediated the conversion of near-infrared radiation into heat, causing the release of a chemotherapeutic as well as thermally induced cell damage. This local, triple-combination therapy can be adapted to other cancer cell types and to molecular targets associated with disease progression.

Idioma originalInglés
Páginas (desde-hasta)1128-1138
Número de páginas11
PublicaciónNature Materials
Volumen15
N.º10
DOI
EstadoPublicada - 1 oct 2016
Publicado de forma externa

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