Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

Josep Sauri; Wolfgang Bermel; Alexei V. Buevich; Edward C. Sherer; Leo A. Joyce; Maged H. M. Sharaf; Paul L. Schiff; Teodor Parella; R. Thomas Williamson; Gary E. Martin

doi:10.1002/anie.201502540

Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

Josep Sauri, Wolfgang Bermel, Alexei V. Buevich, Edward C. Sherer, Leo A. Joyce, Maged H. M. Sharaf, Paul L. Schiff, Teodor Parella, R. Thomas Williamson, Gary E. Martin

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

51 Citas (Scopus)

Resumen

Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1, n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.

Idioma original	Inglés
Páginas (desde-hasta)	10160-10164
Número de páginas	5
Publicación	Angewandte Chemie - International Edition
Volumen	54
N.º	35
DOI	https://doi.org/10.1002/anie.201502540
Estado	Publicada - 24 ago 2015
Publicado de forma externa	Sí

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abstract = "Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1, n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.",

keywords = "DFT calculations, Hd-adequate, NMR spectroscopy, Cryptolepis alkaloids, Homodecoupling",

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AU - Joyce, Leo A.

AU - Sharaf, Maged H. M.

AU - Schiff, Paul L.

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AU - Martin, Gary E.

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KW - DFT calculations

KW - Hd-adequate

KW - NMR spectroscopy

KW - Cryptolepis alkaloids

KW - Homodecoupling

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Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

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