Efficient synthesis of racemic and chiral alkenyl sulfoxides by palladium-catalyzed Suzuki coupling

Gisela Mancha, Ana B. Cuenca, Nuria Rodríguez, Mercedes Medio-Simón, Gregorio Asensio

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva

5 Citas (Scopus)

Resumen

Alkenyl sulfoxide derivatives are obtained in high yields through a palladium-catalyzed Suzuki/Miyaura cross-coupling reaction of racemic and chiral 1-halo sulfoxides with aryl and alkenyl boronic acids. Chiral substrates react with no loss of optical purity and high optical yields. The reaction takes place with different palladium catalysts, such as Pd(PPh3)4 or Pd(OAc)2/DABCO. Although nitrogen ligands like DABCO lead to an active palladium catalyst, they are less effective than the phosphine ones.

Idioma originalInglés
Páginas (desde-hasta)6901-6905
Número de páginas5
PublicaciónTetrahedron
Volumen66
N.º34
DOI
EstadoPublicada - 21 ago 2010
Publicado de forma externa

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