TY - JOUR
T1 - Effect of pistachio consumption on plasma lipoprotein subclasses in pre-diabetic subjects
AU - Hernández-Alonso, P.
AU - Salas-Salvadó, J.
AU - Baldrich-Mora, M.
AU - Mallol, R.
AU - Correig, X.
AU - Bulló, M.
N1 - Funding Information:
We thank the American Pistachio Growers (USA) , and Paramount Farms for their funding support. None of the funding sources played a role in the design, collection, analysis, or interpretation of the data or in the decision to submit the manuscript for publication. We are indebted to the participants in the study and the medical doctors and nursing staff of the SAGESSA group for their collaboration. We thank Carles Munné (Rovira i Virgili University, Reus, Spain) for his editorial assistance. J. Salas-Salvadó is a nonpaid member of the Scientific Advisory Council of the International Nut Council. P. Hernández-Alonso is the recipient of a pre-doctoral fellowship from the Generalitat de Catalunya's Department of Universities [FI-DGR 2014]. M. Baldrich-Mora, R. Mallol, X. Correig and M. Bulló have nothing to declare.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015
Y1 - 2015
N2 - Background and aims: Nuts have been demonstrated to improve several cardiovascular risk factors and the lipid profile in diabetic and pre-diabetic subjects. However, analysis of conventional serum lipid profiles does not completely explain the atherogenic risk associated with pre-diabetes. We therefore investigated whether chronic consumption of pistachio modifies the lipoprotein subclasses to a healthier profile in pre-diabetic subjects. Methods and results: Randomized cross-over clinical trial in 54 subjects with pre-diabetes. Subjects consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Diets were isocaloric and matched for protein, fiber and saturated fatty acids. Nuclear magnetic resonance (NMR) was performed to determine changes in plasma lipoprotein subclasses. Small low-density lipoprotein particles (sLDL-P) significantly decreased after pistachio consumption compared to the nut-free diet (P=0.023). The non-high-density lipoprotein particles (non-HDL-P i.e. VLDL-P plus LDL-P) significantly decreased under the PD compared to CD (P=0.041). The percentage of sHDL-P increased by 2.23% after the PD compared with a reduction of 0.08% after the CD (P=0.014). Consequently, the overall size of HDL-P significantly decreased in the PD (P=0.007). Conclusion: Chronic pistachio consumption could modify the lipoprotein particle size and subclass concentrations independently of changes in total plasma lipid profile, which may help to explain the decreased risk of cardiovascular disease and mortality associated with those individuals who frequently consumed nuts.
AB - Background and aims: Nuts have been demonstrated to improve several cardiovascular risk factors and the lipid profile in diabetic and pre-diabetic subjects. However, analysis of conventional serum lipid profiles does not completely explain the atherogenic risk associated with pre-diabetes. We therefore investigated whether chronic consumption of pistachio modifies the lipoprotein subclasses to a healthier profile in pre-diabetic subjects. Methods and results: Randomized cross-over clinical trial in 54 subjects with pre-diabetes. Subjects consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Diets were isocaloric and matched for protein, fiber and saturated fatty acids. Nuclear magnetic resonance (NMR) was performed to determine changes in plasma lipoprotein subclasses. Small low-density lipoprotein particles (sLDL-P) significantly decreased after pistachio consumption compared to the nut-free diet (P=0.023). The non-high-density lipoprotein particles (non-HDL-P i.e. VLDL-P plus LDL-P) significantly decreased under the PD compared to CD (P=0.041). The percentage of sHDL-P increased by 2.23% after the PD compared with a reduction of 0.08% after the CD (P=0.014). Consequently, the overall size of HDL-P significantly decreased in the PD (P=0.007). Conclusion: Chronic pistachio consumption could modify the lipoprotein particle size and subclass concentrations independently of changes in total plasma lipid profile, which may help to explain the decreased risk of cardiovascular disease and mortality associated with those individuals who frequently consumed nuts.
KW - Cardiovascular disease
KW - Clinical trial
KW - Dietary intervention
KW - Lipoprotein
KW - Pistachios
KW - Pre-diabetes
UR - http://www.scopus.com/inward/record.url?scp=84933680154&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2015.01.013
DO - 10.1016/j.numecd.2015.01.013
M3 - Article
C2 - 25791863
AN - SCOPUS:84933680154
SN - 0939-4753
VL - 25
SP - 396
EP - 402
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 4
ER -
