Resumen
Planarians are flatworms capable of whole-body regeneration, able to regrow any missing body part after injury or amputation. The extraordinary regenerative capacity of planarians is based upon the presence in the adult of a large population of somatic pluripotent stem cells. These cells, called neoblasts, offer a unique system to study the process of stem cell specification and differentiation in vivo. In recent years, FACS-based isolation of neoblasts, RNAi functional analyses as well as high-throughput approaches such as single-cell sequencing have allowed a rapid progress in our understanding of many different aspects of neoblast biology. Here, we summarize our current knowledge on the molecular signatures that define planarian neoblasts heterogeneity, which includes a percentage of truly pluripotent stem cells, and guide the commitment of pluripotent ne-oblasts into lineage-specific progenitor cells, as well as their differentiation into specific planarian cell types.
Idioma original | Inglés |
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Número de artículo | 1532 |
Número de páginas | 23 |
Publicación | Biomolecules |
Volumen | 11 |
N.º | 10 |
DOI | |
Estado | Publicada - oct 2021 |
Publicado de forma externa | Sí |