@article{bcf9b4fdbab64dfe98175c7259156c66,
title = "Copper-Catalyzed Borylative Ring Closing C-C Coupling toward Spiro- and Dispiroheterocycles",
abstract = "The synthesis of spiroheterocyclic structures with a pendant methylene boronate substituent has been accomplished to promote further functionalization. A Cu-catalyzed borylative ring closing C-C coupling of an alkenyl halide is the key step toward the synthesis of [m.n]-spirocycles (m,n = 3-5). Computational studies on the mechanism reproduced all the experimental trends and explain the enhanced reactivity of systems leading to strained smaller rings. The optimized protocol also gives access to dispirocycle scaffolds, fully characterized by X-ray diffraction.",
author = "Jordi Royes and Shaofei Ni and Albert Farr{\'e} and {La Cascia}, Enrico and Carb{\'o}, {Jorge J.} and Cuenca, {Ana B.} and Feliu Maseras and Elena Fern{\'a}ndez",
note = "Funding Information: This research was supported by MINECO through projects CTQ2016-80328-P and CTQ2017-87792-R and the Severo Ochoa Excellence Accreditation 2014−2018 through project SEV-2013-0319, and by Generalitat de Catalunya through the CERCA Programme and Feder. We thank Dr. A. A. Trabanco (Janssen) for useful discussions/suggestions about the content of the article. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = apr,
day = "6",
doi = "10.1021/acscatal.8b00257",
language = "English",
volume = "8",
pages = "2833--2838",
journal = "ACS Catalysis",
issn = "2155-5435",
publisher = "American Chemical Society",
number = "4",
}