Computer-assisted optimization in HPLC

L. G. Sabaté; A. M. Díaz; X. M. Tomás; M. M. Gassiot

doi:10.1093/chromsci/21.10.439

Computer-assisted optimization in HPLC

L. G. Sabaté^*
, A. M. Díaz
, X. M. Tomás
, M. M. Gassiot

^*Autor/a de correspondencia de este trabajo

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

11 Citas (Scopus)

Resumen

A program in BASIC is proposed for ‘off-line’ optimization of experimental parameters in HPLC by the Simplex sequential method. The program is modular and permits adaptation of the chromatographic resolution definition to the user’s needs with a minimum of programming knowledge. The program is applied to improve separation of 2,4-dinitrophenylhydrazones of isolated carbonyl compounds in beer. The optimized parameters are: flow, initial methanol concentration, concentration gradient, and initial isocratic time.

Idioma original	Inglés
Páginas (desde-hasta)	439-443
Número de páginas	5
Publicación	Journal of Chromatographic Science
Volumen	21
N.º	10
DOI	https://doi.org/10.1093/chromsci/21.10.439
Estado	Publicada - oct 1983
Publicado de forma externa	Sí

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abstract = "A program in BASIC is proposed for {\textquoteleft}off-line{\textquoteright} optimization of experimental parameters in HPLC by the Simplex sequential method. The program is modular and permits adaptation of the chromatographic resolution definition to the user{\textquoteright}s needs with a minimum of programming knowledge. The program is applied to improve separation of 2,4-dinitrophenylhydrazones of isolated carbonyl compounds in beer. The optimized parameters are: flow, initial methanol concentration, concentration gradient, and initial isocratic time.",

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AU - Sabaté, L. G.

AU - Díaz, A. M.

AU - Tomás, X. M.

AU - Gassiot, M. M.

PY - 1983/10

Y1 - 1983/10

N2 - A program in BASIC is proposed for ‘off-line’ optimization of experimental parameters in HPLC by the Simplex sequential method. The program is modular and permits adaptation of the chromatographic resolution definition to the user’s needs with a minimum of programming knowledge. The program is applied to improve separation of 2,4-dinitrophenylhydrazones of isolated carbonyl compounds in beer. The optimized parameters are: flow, initial methanol concentration, concentration gradient, and initial isocratic time.

AB - A program in BASIC is proposed for ‘off-line’ optimization of experimental parameters in HPLC by the Simplex sequential method. The program is modular and permits adaptation of the chromatographic resolution definition to the user’s needs with a minimum of programming knowledge. The program is applied to improve separation of 2,4-dinitrophenylhydrazones of isolated carbonyl compounds in beer. The optimized parameters are: flow, initial methanol concentration, concentration gradient, and initial isocratic time.

UR - https://www.scopus.com/pages/publications/0020840871

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DO - 10.1093/chromsci/21.10.439

M3 - Article

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Computer-assisted optimization in HPLC

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