TY - CHAP
T1 - CHAPTER 4
T2 - Photodynamic Therapy
AU - Hally, Cormac
AU - Rodríguez-Amigo, Beatriz
AU - Bresolí-Obach, Roger
AU - Planas, Oriol
AU - Nos, Jaume
AU - Boix-Garriga, Ester
AU - Ruiz-González, Rubén
AU - Nonell, Santi
N1 - Funding Information:
Part of the research described in this chapter has been supported by the Spanish ministerio de economía y Competitividad through grant no. CTQ2013-48767-C3-1-R. C. h. thanks IQS and eurofragance for a fellowship. B. R.-a. thanks FeRReR and O. P. and R. B.-O. thanks the SuR del DeC de la generalitat de Catalunya (grants No. 2015 FI_B1 00063 and 2015 FI_B 00315) for their respective predoctoral fellowships. S. N. is very grateful to his former students and collaborators for their contribution to some of the work described herein. Finally we would like to thank all the researchers who have contributed to this field and whose names are listed in the references.
Publisher Copyright:
© The Royal Society of Chemistry 2018.
PY - 2018
Y1 - 2018
N2 - Photodynamic therapy is a clinical technique for the treatment of cancers, microbial infections and other medical conditions by means of light-induced generation of reactive oxygen species using photosensitising drugs. The intrinsic fluorescence of many such drugs make them potential theranostic agents for simultaneous diagnosis and therapy. This chapter reviews the basic chemical and biological aspects of photodynamic therapy with an emphasis on its applications in theranostics. The roles of nanotechnology is highlighted, as well as emerging trends such as photoimmunotherapy, image-guided surgery and light-and singlet-oxygen dosimetry.
AB - Photodynamic therapy is a clinical technique for the treatment of cancers, microbial infections and other medical conditions by means of light-induced generation of reactive oxygen species using photosensitising drugs. The intrinsic fluorescence of many such drugs make them potential theranostic agents for simultaneous diagnosis and therapy. This chapter reviews the basic chemical and biological aspects of photodynamic therapy with an emphasis on its applications in theranostics. The roles of nanotechnology is highlighted, as well as emerging trends such as photoimmunotherapy, image-guided surgery and light-and singlet-oxygen dosimetry.
UR - http://www.scopus.com/inward/record.url?scp=85041491809&partnerID=8YFLogxK
U2 - 10.1039/9781788010597-00086
DO - 10.1039/9781788010597-00086
M3 - Chapter
AN - SCOPUS:85041491809
T3 - RSC Drug Discovery Series
SP - 86
EP - 122
BT - Drug Discovery for Leishmaniasis
A2 - Thanou, Maya
PB - Royal Society of Chemistry
ER -
