Cationic porphycenes as potential photosensitizers for antimicrobial photodynamic therapy

Xavier Ragàs, David Sánchez-García, Rubén Ruiz-González, Tianhong Dai, Montserrat Agut, Michael R. Hamblin, Santi Nonell

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva

107 Citas (Scopus)

Resumen

Structures of typical photosensitizers used in antimicrobial photodynamic therapy are based on porphyrins, phthalocyanines, and phenothiazinium salts, with cationic charges at physiological pH values. However, derivatives of the porphycene macrocycle (a structural isomer of porphyrin) have barely been investigated as antimicrobial agents. Therefore, we report the synthesis of the first tricationic water-soluble porphycene and its basic photochemical properties. We successfully tested it for in vitro photoinactivation of different Gram-positive and Gram-negative bacteria, as well as a fungal species (Candida) in a drug-dose and light-dose dependent manner. We also used the cationic porphycene in vivo to treat an infection model comprising mouse third degree burns infected with a bioluminescent methicillin-resistant Staphylococcus aureus strain. There was a 2.6-log10 reduction (p < 0.001) of the bacterial bioluminescence for the PDT-treated group after irradiation with 180 J•cm-2 of red light.

Idioma originalInglés
Páginas (desde-hasta)7796-7803
Número de páginas8
PublicaciónJournal of Medicinal Chemistry
Volumen53
N.º21
DOI
EstadoPublicada - 11 nov 2010

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