TY - JOUR
T1 - BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium
AU - Lucana, Maria C.
AU - Gosselet, Fabien
AU - Díaz-Perlas, Cristina
AU - Oller-Salvia, Benjamí
AU - Lucchi, Roberta
N1 - Publisher Copyright:
© 2024 RSC.
PY - 2024/1
Y1 - 2024/1
N2 - Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.
AB - Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.
KW - Shuttle peptides
KW - Barrier
KW - Antibodies
KW - Selection
UR - https://www.scopus.com/pages/publications/85179614776
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:001119537600001&DestLinkType=FullRecord&DestApp=WOS_CPL
UR - http://hdl.handle.net/20.500.14342/5186
U2 - 10.1039/d3cb00194f
DO - 10.1039/d3cb00194f
M3 - Article
C2 - 38179197
AN - SCOPUS:85179614776
SN - 2633-0679
VL - 5
SP - 7
EP - 11
JO - RSC Chemical Biology
JF - RSC Chemical Biology
IS - 1
ER -