Resumen
Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.
| Idioma original | Inglés |
|---|---|
| Número de artículo | 537 |
| Publicación | Antioxidants |
| Volumen | 8 |
| N.º | 11 |
| DOI | |
| Estado | Publicada - nov 2019 |
| Publicado de forma externa | Sí |
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En: Antioxidants, Vol. 8, N.º 11, 537, 11.2019.
Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva
TY - JOUR
T1 - Associations between dietary polyphenols and type 2 diabetes in a cross-sectional analysis of the PREDIMED-Plus trial
T2 - Role of body mass index and sex
AU - Tresserra-Rimbau, Anna
AU - Castro-Barquero, Sara
AU - Vitelli-Storelli, Facundo
AU - Becerra-Tomas, Nerea
AU - Vázquez-Ruiz, Zenaida
AU - Díaz-López, Andrés
AU - Corella, Dolores
AU - Castañer, Olga
AU - Romaguera, Dora
AU - Vioque, Jesús
AU - Alonso-Gómez, Ángel María
AU - Wärnberg, Julia
AU - Martínez, José Alfredo
AU - Serra-Majem, Lluís
AU - Estruch, Ramon
AU - Tinahones, Francisco José
AU - Lapetra, José
AU - Pintó, Xavier
AU - Tur, Josep Antoni
AU - López-Miranda, José
AU - García-Molina, Laura
AU - Delgado-Rodríguez, Miguel
AU - Matía-Martín, Pilar
AU - Daimiel, Lidia
AU - Rubín-García, María
AU - Vidal, Josep
AU - Galdon, Alba
AU - Ros, Emilio
AU - Basterra-Gortari, Francisco Javier
AU - Babio, Nancy
AU - Sorlí, José Vicente
AU - Hernáez, Álvaro
AU - Konieczna, Jadwiga
AU - Notario-Barandiaran, Leyre
AU - Tojal-Sierra, Lucas
AU - Pérez-López, Jessica
AU - Abete, Itziar
AU - Álvarez-Pérez, Jacqueline
AU - Fernández-García, José Carlos
AU - Santos-Lozano, José Manuel
AU - Galera-Cusí, Ana
AU - Julibert, Alicia
AU - Ruiz-Canela, Miguel
AU - Martinez-Lacruz, Raul
AU - Pérez-Vega, Karla Alejandra
AU - Galmes-Panades, Aina María
AU - Pastor-Polo, Concepción
AU - Moreno-Rodriguez, Anai
AU - Gea, Alfredo
AU - Fitó, Montserrat
AU - Lamuela-Raventós, Rosa María
AU - Salas-Salvadó, Jordi
N1 - Funding Information: Funding: The PREDIMED-Plus trial was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts. J.K. was supported by the “FOLIUM” program within the FUTURMed project entitled Talent for the medicine within the future from the Fundació Institut d’Investigació Sanitària Illes Balears. This call was co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. Funding Information: Conflicts of Interest: R.E. reports grants from Cerveza y Salud, Spain, and Fundacion Dieta Mediterranea, Spain. Additionally, personal fees for given lectures from Brewers of Europe, Belgium; Fundacion Cerveza y Salud, Spain; Pernod Ricard, Mexico; Instituto Cervantes, Albuquerque, NM, USA; Instituto Cervantes, Milan, Italy; Instituto Cervantes, Tokyo, Japan; Lilly Laboratories, Spain; and Wine and Culinary International Forum, Spain; and non-financial support to organize a National Congress on Nutrition. R.M.L.-R. reports personal fees from Cerveceros de España, personal fees and other from Adventia, other from Ecoveritas, S.A., outside the submitted work. The rest of the authors have declared that no competing interests exist. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. E.R. reports grants, personal fees, non-financial support and other from California Walnut Commission, during the conduct of the study; grants, personal fees, non-financial support and other from Alexion, grants, personal fees and other from Sanofi Aventis, personal fees, non-financial support and other from Ferrer International, personal fees, non-financial support and other from Danone, personal fees and non-financial support from Merck Sharp Dohme, personal fees and other from Amarin, outside the submitted work. Funding Information: The PREDIMED-Plus trial was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatolog?a de la Obesidad y Nutrici?n (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigaci?n para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926), the Especial Action Project entitled Implementaci?n y evaluaci?n de una intervenci?n intensiva sobre la actividad f?sica Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014?2019, 340918) to M.?.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejer?a de Salud de la Junta de Andaluc?a (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovaci?n y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts. J.K. was supported by the ?FOLIUM? program within the FUTURMed project entitled Talent for the medicine within the future from the Fundaci? Institut d?Investigaci? Sanit?ria Illes Balears. This call was co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. Funding Information: Acknowledgments: We thank all the volunteers for their participation in and the personnel for their contribution to the PREDIMED-Plus trial. CIBEROBN, CIBERESP, and CIBERDEM are initiatives of Instituto de Salud Carlos III (ISCIII), Madrid, Spain. A.T.-R. thanks the Ministry of Science Innovation and Universities for the Juan de la Cierva-formación contract. Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/11
Y1 - 2019/11
N2 - Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.
AB - Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.
KW - Catechins
KW - Diet
KW - Flavonoids
KW - Hydroxybenzoic acids
KW - Hydroxycinnamic acids
KW - Lignans
KW - Obesity
KW - Phenolic acids
KW - Proanthocyanidins
UR - http://www.scopus.com/inward/record.url?scp=85076531826&partnerID=8YFLogxK
U2 - 10.3390/antiox8110537
DO - 10.3390/antiox8110537
M3 - Article
AN - SCOPUS:85076531826
SN - 2076-3921
VL - 8
JO - Antioxidants
JF - Antioxidants
IS - 11
M1 - 537
ER -