TY - JOUR
T1 - Anthracene-based fluorescent nanoprobes for singlet oxygen detection in biological media
AU - Bresolí-Obach, Roger
AU - Nos, Jaume
AU - Mora, Margarita
AU - Sagristà, Maria Lluïsa
AU - Ruiz-González, Rubén
AU - Nonell, Santi
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/10/15
Y1 - 2016/10/15
N2 - We have developed a novel singlet oxygen nanoprobe based on 9,10-anthracenedipropionic acid covalently bound to mesoporous silica nanoparticles. The nanoparticle protects the probe from interactions with proteins, which detract from its ability to detect singlet oxygen. In vitro studies show that the nanoprobe is internalized by cells and is distributed throughout the cytoplasm, thus being capable of detecting intracellularly-generated singlet oxygen.
AB - We have developed a novel singlet oxygen nanoprobe based on 9,10-anthracenedipropionic acid covalently bound to mesoporous silica nanoparticles. The nanoparticle protects the probe from interactions with proteins, which detract from its ability to detect singlet oxygen. In vitro studies show that the nanoprobe is internalized by cells and is distributed throughout the cytoplasm, thus being capable of detecting intracellularly-generated singlet oxygen.
KW - Anthracene dipropionic acid
KW - Confocal microscopy
KW - Fluorescent probe
KW - HeLa cells
KW - Silica nanoparticles
KW - Singlet oxygen
UR - https://www.scopus.com/pages/publications/84994710623
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000386988600008&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1016/j.ymeth.2016.06.007
DO - 10.1016/j.ymeth.2016.06.007
M3 - Article
C2 - 27302662
AN - SCOPUS:84994710623
SN - 1046-2023
VL - 109
SP - 64
EP - 72
JO - Methods
JF - Methods
ER -